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The purpose of this study is to determine whether hydrocortisone biases formation of alcohol-related memories to potentiate drinking.
This study aims to 1) Characterize the effect of elevated glucocorticoids during encoding on long-term memory for alcohol-related information; 2) Identify the neural mechanisms by which glucocorticoids influence encoding of alcohol-related experiences; and 3) Determine how glucocorticoid modulation of alcohol-related encoding relates to drinking after retrieving alcohol-related memories.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hydrocortisone | Experimental | Participants receive hydrocortisone (20mg) |
|
| placebo | Placebo Comparator | Participants receive placebo. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hydrocortisone 20 MG | Drug | Participants receive Hydrocortisone 20 MG |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Changes fMRI signal | Changes in fMRI signal at encoding will be assessed over an hour long period. | 1 hour |
| Item memory | Item memory will be assessed through performance on delayed memory assessments. Item memory is determined by the accuracy of memory for individual items and will be expressed as dprime. | Up to 90 minutes |
| Context memory | Context memory will be assessed through performance on delayed memory assessments. Context memory is determined by the accuracy of memory for associated contexts and will be expressed as % correct. | Up to 90 minutes |
| Affect memory | Affect memory will be assessed through performance on delayed memory assessments. Affect memory is determined by subjective ratings of vividness (1-4), change in ratings from encoding to retrieval of memory (0-3). The score is averaged where a higher score indicates greater affect. | Up to 90 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Alcohol motivation | Performance on alcohol taste test following memory retrieval will be assessed using the Alcohol Taste Test (ATT). The test asks participants to taste the alcohol in each two containers to identify whether the alcohol was the same or different. The % correct is used to assess this outcome. | 10 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elizabeth V Goldfarb, PhD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yale University | New Haven | Connecticut | 06511 | United States |
Individual participant data that underlie the results reported in published articles will be shared after de-identification.
Immediately following publication with no end date.
Anyone who wishes to have access to the data may do so.
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| ID | Term |
|---|---|
| D000428 | Alcohol Drinking |
| D004327 | Drinking Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D006854 | Hydrocortisone |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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| Placebo |
| Other |
Participants receive placebo |
|
| Affect - Negative |
Self-reported measures of emotional state following drug administration and memory retrieval using the PANAS. The negative subscale of the PANAS will be used and has a range of 10-50. Higher scores indicate higher negative affect. |
| 10 minutes |
| Affect - Positive | Self-reported measures of emotional state following drug administration and memory retrieval using the PANAS. The negative subscale of the PANAS will be used and has a range of 10-50. Higher scores indicate higher positive affect. | 10 minutes |
| Neuroendocrine/cortisol reactivity | Change in salivary cortisol levels following the hydrocortisone/placebo administration. | Baseline to 2 hours |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D015062 | 11-Hydroxycorticosteroids |
| D006889 | Hydroxycorticosteroids |
| D000305 | Adrenal Cortex Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D015065 | 17-Hydroxycorticosteroids |