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Adenomyosis can be defined as the settling of endometrial gland cells in the myometrium and deformity in the uterus and the prevalence of adenomyosis is according to the patient population and countries around 20%. There are recent publications reporting that this rate increases up to 50% in women dealing with infertility. In adenomyosis, where uterine morphology is affected, it is not thought that the uterus, which is expected to provide many morphological adaptations during pregnancy, will not be affected. Therefore, in this prospective study, it was planned to investigate the effects of adenomyosis during pregnancy.
For this study the presence of adenomyosis will be questioned by using ultrasonographic morphological uterine limitation (MUSA) in women who apply to the outpatient clinic with suspicion of pregnancy and undergo transvaginal ultrasonography for the diagnosis of pregnancy before sixth gestational week.
Patients will be divided into two groups according to the presence of adenomyosis and pregnancy complications such as preterm labor, premature rupture of membranes, cesarean section rates, preeclampsia, fetal malpresentation and preeclampsia will be compared between the groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adenomyosis Group |
| ||
| Non-adenomyosis Group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non intervention | Other | During the study there is no extra intervention planned for the participants. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pregnancy complication | Preterm labour | 15 month |
| Measure | Description | Time Frame |
|---|---|---|
| Pregnancy complication | placental anomalies | 16 month |
| Pregnancy complication | preeclampsia, eclampsia | 17 month |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant women diagnosed by TV usg before the 6th gestational week will be divided into two according to the MUSA classification, and those with adenomyosis who are not in the study group will be evaluated as the control group.
All the participants should be at between 18-35 age years old and all perinatal visits and deliveries should be at Tepecik Obstetric Clinic.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abdurrahman Hamdi İnan, Assoc. Prof. | Contact | (0232) 373 89 21 | ahamdiinan@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ahkam Göksel Kanmaz, Assoc. Prof. | Tepecik Education and Research Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tepecik Education and Research Hospital | Recruiting | Izmir | Turkey (TĂĽrkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31374085 | Background | Harada T, Taniguchi F, Amano H, Kurozawa Y, Ideno Y, Hayashi K, Harada T; Japan Environment and Children's Study Group. Adverse obstetrical outcomes for women with endometriosis and adenomyosis: A large cohort of the Japan Environment and Children's Study. PLoS One. 2019 Aug 2;14(8):e0220256. doi: 10.1371/journal.pone.0220256. eCollection 2019. | |
| 31318420 |
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| ID | Term |
|---|---|
| D062788 | Adenomyosis |
| D011248 | Pregnancy Complications |
| ID | Term |
|---|---|
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2019 Sep 11;25(5):592-632. doi: 10.1093/humupd/dmz012. |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |