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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2021-02616 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| 43000 | Other Identifier | Medical College of Wisconsin | |
| K01AG065485 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.
PRIMARY OBJECTIVES:
I. Examine associations between social support, strain, and isolation and phenotypic aging over the 1-year recovery period.
II. Examine associations between social support, strain, and isolation and biological aging over the 1-year recovery period.
III. Test biological aging as a mediator linking social processes and phenotypic aging.
EXPLORATORY OBJECTIVE:
I. Test sex differences in Aims 1 and 2.
OUTLINE:
Adopting a prospective design, participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives16. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome-wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supportive care (EAR, questionnaires, biospecimen collection) | Participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biospecimen Collection | Procedure | Undergo collection of blood sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| The number of participants with gene expression of cellular senescence marker p16. | This will be measured by mRNA/gene expression. | Day 100 and 1 year post-transplant |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing HCT for hematologic cancers.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Medical College of Wisconsin Cancer Center Clinical Trials Office | Contact | 866-680-0505 | 8900 | cccto@mcw.edu |
| Name | Affiliation | Role |
|---|---|---|
| Kelly Rentscher, PhD | Medical College of Wisconsin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Froedtert Hospital and the Medical College of Wisconsin | Recruiting | Milwaukee | Wisconsin | 53226 | United States |
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| ID | Term |
|---|---|
| D019337 | Hematologic Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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Blood
| Electronic Health Record Review | Other | Review of medical records |
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| Questionnaire Administration | Other | Complete questionnaires |
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