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Retinal tissue parameters of pediatric patients with vitamin D deficiency will be evaluated in this prospective case-control study. The patients will be divided into 2 groups according to the vitamin D level. Retinal vessel diameters, retinal nerve fiber evaluation, choroidal thickness will be evaluated. Choroidal thinning decrease in retinal artery diameter and increase in retinal vein diameter will be detected in the vitamin D deficiency group.
The study of the relationship between vitamin D status and retinal diseases is a new concept, and there is a large gap in research focusing on the pediatric population in the literature. The importance of vitamin D in retinal maturation and its role in the development of retinal diseases at a young age is being investigated. In this sense, as far as known, it is the first study investigating retinal structure parameters in pediatric patients with vitamin D deficiency.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pediatric endocrinologist | Active Comparator | Patient selection by pediatric endocrinologist on the basis of vitamin D |
|
| Ophthalmologist | No Intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin D deficiency | Dietary Supplement | Ocular significance of vitamin D deficiency in pediatric cases |
|
| Measure | Description | Time Frame |
|---|---|---|
| choroidal thickness | subfoveal, and subfoveal 1500-µm- and 3000-µm-diameter distance nasal and temporal areas | up to 3 months |
| retinal nerve fiber layer | Retinal nerve fiber layer will be detected by optical coherence tomography | up to 3 months |
| The central retinal artery and vein calibers | The central retinal artery and vein calibers will be analyzed with the Interactive Vessel Analyzer | up to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| blood vitamin D levels | vitamin D deficiency or normal effects of vitamin D deficiency | up to 3 months |
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Inclusion Criteria:(Group 1):
Exclusion Criteria:
Pediatrics population
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| Name | Affiliation | Role |
|---|---|---|
| Emre Aydemir, M.D. | Adiyaman University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Adıyaman U | Adıyaman | None Selected | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23936865 | Result | Poon M, Craig ME, Kaur H, Cusumano J, Sasongko MB, Wong TY, Donaghue KC. Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes. J Diabetes Res. 2013;2013:280691. doi: 10.1155/2013/280691. Epub 2013 Jul 7. |
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Participants will be told what the plan provided and how it worked. Information will be given about when he will participate in the study and the measurements to be taken for the study.
It will be emphasized that there was nothing that harmed the participants in the examinations.
Participants will be examined at same times of the day in order not to affect the measurement results.
Participants will be divided into groups according to their vitamin D levels
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| ID | Term |
|---|---|
| D014808 | Vitamin D Deficiency |
| D012164 | Retinal Diseases |
| D015862 | Choroid Diseases |
| D009901 | Optic Nerve Diseases |
| ID | Term |
|---|---|
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
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Group 1: 1) age <18 years old; 2) serum vitamin D [(25(OH) D), calcitriol] level <20 ngr/mL in previous two weeks Group 2: 1) age <18 years old; 2) serum vitamin D [(25(OH) D), calcitriol] level >20 ngr/mL in previous two weeks
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Patients will be examined without knowing their vitamin D level. The OCT evaluations will be performed by a highly trained ophthalmic technician, and the compatibility of the results will be confirmed by two experienced retinal specialists.
| D009750 |
| Nutritional and Metabolic Diseases |
| D005128 | Eye Diseases |
| D014603 | Uveal Diseases |
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |