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Transplantation of Allogenic Adipose Mesenchimal Stem cell in hypoxic cultur condition with Ligament- derived conitioned medium can enhance regeneration of posterior cruciate ligament rupture
this study is in vivo study to prove effect of transplantation of Allogenic Adipose Mesenchimal Stem cell in hypoxic cultur condition with Ligament- derived conitioned medium in regeneration of posterior cruciate ligament rupture
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Placebo Comparator | rabbit with posterior cruciate ligament rupture and treated with fibrin glue (sacffold) |
|
| conditioned medium group | Active Comparator | rabbit with posterior cruciate ligament rupture and treated with fibrin glue mix with ligament derived conditioned medium |
|
| stem cells group | Active Comparator | rabbit with posterior cruciate ligament rupture and treated with fibrin glue mix with adypose mesenchymal stem cells in hypoxic culture condition |
|
| composite group | Experimental | rabbit with posterior cruciate ligament rupture and treated with fibrin glue mix with adypose mesenchymal stem cells in hypoxic culture condition and ligament derived conditioned medium |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| adypose mesenchymal conditioned medium and ligament derived conditioned medium | Biological | rabbit with posterior cruciate ligament rupture and treated with fibrin glue mix with adypose mesenchymal stem cells in hypoxic culture and ligament derived conditioned medium |
| Measure | Description | Time Frame |
|---|---|---|
| tensile strength of posterior cruciate ligament | measurement of tensile strength of posterior cruciate ligament | 6 weeks |
| Thrombosite of Growth Factor - beta 1 | measurement value of Thrombosite Growth Factor - beta 1 | 6 weeks |
| basic fibroblast of growth factor | measurement value of basic fibroblast of growth factor | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
white male rabbit
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| sholahuddin rhatomy, MD | Contact | +62 274 588688 | 17225 | rhatomy.s@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sholahuddin Rhatomy | Recruiting | Sleman | Special Region of Yogyakarta | 55571 | Indonesia |
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