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| Name | Class |
|---|---|
| Istanbul Kent University | OTHER |
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An experimental study examining wound healing in 5 different groups on 30 rats.
Magnesium topically increases collagen synthesis and angiogenesis, providing faster and higher quality wound healing. In addition, with its analgesic effect, it will also eliminate the pain sensation caused by the wound and increase the quality of life of the patient whose skin integrity is impaired.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group placebo | Placebo Comparator | Isotonic solution will be administered daily to 6 female rats. |
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| Group sham | Sham Comparator | Base cream to be applied twice a day to 6 female rats. |
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| Group %1 mgso4 | Experimental | Cream containing 1% MgSO4 will be applied twice a day to 6 female rats. |
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| Group %10 MgSO4 | Experimental | Cream containing 10% MgSO4 will be applied twice a day to 6 female rats. |
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| Group positive control | Active Comparator | Cream containing centella asiatica will be applied twice a day to 6 female rats. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| placebo comparator | Other | solution containing 0.9 % sodium chlorine |
| |
| Measure | Description | Time Frame |
|---|---|---|
| 7th day evaluation | Histopathological evaluation of wound healing comparing with the rate of vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta) and hydroxyproline at immunohistochemical staining with biopsy on the 7th day. | 7th day |
| Measure | Description | Time Frame |
|---|---|---|
| 15th day evaluation | Histopathological evaluation of wound healing comparing with the rate of VEGF, TGF-beta and hydroxyproline at immunohistochemical staining with biopsy on the 15th day. | 15th day |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Başakşehir Çam Ve Sakura Hospital | Istanbul | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| C526146 | Centella asiatica extract |
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| sham comparator |
| Other |
vaseline, beeswax,polyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water |
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| Experimental drug 1 | Other | A cream containing 10 % MgSO4.vaseline, beeswaxpolyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water |
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| Experimental drug 2 | Other | A cream containing 10 % MgSO4.vaseline, beeswax,polyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water |
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| Centella asiatica | Drug | A cream containing Centella asiatica |
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