A Multicenter, Evaluator-Blinded, No-Treatment Control Design Clinical Study to Evaluate the Effectiveness and Safety of YVOIRE Y-Solution 720 Injected for Jawline Contouring

This is a Multicenter, Randomized, Evaluator-Blinded, No-Treatment Control Design Clinical Study to Evaluate the Effectiveness and Safety of YVOIRE Y-Solution 720 Injected for Jawline Contouring.

Inclusion Criteria:

• Male or female adults 18 - 75 years of age (inclusive)
• 2 (moderate) or 3 (severe) on Jawline Contour Rating Scale (JCRS)
• want a filler injection procedure for the replacement of volume loss in the jawlines

Exclusion Criteria:

• have an active or infective skin disease
• have lower-face volume deficit due to congenital defect, trauma, abnormalities in adipose tissue related to immune-mediated diseases
• have a tattoo or excessive facial hair in the evaluation area
• have received permanent facial implants
• have undergone semi-permanent filler within 24 months
• have undergone temporary dermal filler treatment in the lower face (below the orbital rim) within 12 months
• have streptococcal disease
• have a medical history of hypertrophic cicatrix, hyperpigmentation or keloid
• have a history of anaphylaxis, multiple severe allergies, or allergy to lidocaine (or any amide-based anesthetic), or hyaluronic acid products
• have history of bleeding disorder
• have severe cardiovascular, hepatic or renal diseases considered as per Investigator's discretion
• have known malignant tumors or cancerous or precancerous lesion
• positive pregnancy test indicating pregnancy
• active COVID-19 infection and suspected COVID-19 infection within the past 14 days