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Hypotension after induction of general anesthesia and before surgical stimulation is a prevalent anesthesia-related side effect. The post-induction hypotension disrupts organ perfusion and may cause organ damage particularly acute kidney injury, cerebrovascular stroke, and myocardial ischemia. Post-induction hypotension occurs with greater frequency and severity in the elderly. This is because of aged-related diminished cardiac reserve and impaired autonomic homeostasis. Pleth variability index (PVI) is a software program that measures the dynamic changes of the PI that occurs during a complete respiratory cycle. Our primary outcome is to determine the predictive ability and the optimal cut-off value of pre-anesthesia PVI for predicting elderly patients who are at risk of developing post-induction hypotension
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pleth variability index for prediction of post-induction hypotension | Device | The use of the baseline Pleth variability index values for prediction of occurrence of post-induction hypotension |
| Measure | Description | Time Frame |
|---|---|---|
| The accuracy (Area under receiver operating characteristic curves) of pre-induction PVI for prediction of post-induction hypotension | before induction of general anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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all patients. Patients ≥ 65 years, ASA physical status I or II, and scheduled for elective surgery under general anesthesia will be enrolled in the study.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Abeer Ahmed Mohamed | Maadi | Cairo Governorate | 11728 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42177681 | Derived | Ollaek MA, Ahmed AM, Mohamed MH, Abdelhamid BM, Sewilam MR, Ismaeil SA. Pre-anesthesia pleth variability index and perfusion index for predicting post-induction hypotension in elderly surgical patients: a cohort study. J Anesth. 2026 May 24. doi: 10.1007/s00540-026-03778-w. Online ahead of print. |
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