Effect of Nitrous Oxide on EEG

The Effect of Nitrous Oxide on EEG, a Randomized, Double-blinded Study

Our recent preclinical observations suggest that monitoring of slow electroencephalogram (EEG) oscillations may be used to predict the efficacy of rapid-acting antidepressants such as ketamine or nitrous oxide. In this project we will carry out critical clinical research on healthy volunteers and study the effects of nitrous oxide on EEG. Results will be used for the design of clinical trials on depressed individuals. The project will be done in collaboration between neuroscientists at the University of Helsinki and clinicians at the Tampere University Hospital.

Inclusion Criteria:

1. informed consent obtained
2. age between 18 - 40
3. male
4. body mass index 18 - 27

Exclusion Criteria:

1. Age < 18 or > 40
2. Alcohol Use Disorders Identification Test (AUDIT) >6 points
3. Drug Abuse Screening Test 20 (DAST-20) > 0 points
4. Beck Depression Inventory (BDI) > 11 points
5. Symptom Check List 90 (SCL-90) over mean values of Finnish population in any dimensions of the SCL-90 or the global severity index
6. Any respiratory disorder including sleep apnea
7. Any heart illness
8. Epilepsy
9. Known vitamin B12 deficiency