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The study is being conducted to evaluate the efficacy and safety of SHR-1701 in combination with or without famitinib malate for the treatment of extensive stage small cell lung cancer after the failure of previous systemic chemotherapy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SHR-1701+ Famitinib | Experimental |
| |
| SHR-1701 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SHR-1701ï¼› Famitinib | Drug | SHR-1701+ Famitinib |
| |
| SHR-1701 |
| Measure | Description | Time Frame |
|---|---|---|
| Objective response rate (ORR) based on RECIST 1.1 criteria | up to approximately 1 year. |
| Measure | Description | Time Frame |
|---|---|---|
| Progression free survival (PFS) based on RECIST 1.1 criteria | up to approximately 1 year. | |
| Disease control rate (DCR) based on RECIST 1.1 criteria | up to approximately 1 year. | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wei Shi | Contact | 021-68868570 | wei.shi@hengrui.com | |
| Huan Li | Contact | 17721286513 | huan.li@hengrui.com |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| C000723862 | SHR-1701 |
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SHR-1701 in combination with or without famitinib
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| Drug |
SHR-1701 |
|
| Duration of response (DoR) |
| up to approximately 1 year |
| Overall survival (OS) | up to approximately 1 year |
| AEs+ SAEs determined by NCI-CTCAE V5.0 | Baseline until up to 90 days after end of treatment. |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |