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Brain activation can be studied using the Functional Near InfraRed Spectroscopy (fNIRS). It was shown that CPF activation during walking and during dual task could be different in stroke patients and in healthy subjects.
To date, fNIRS reliability is not completely established during walking and during dual task. Therefore, this study will examine the reproducibility of fNIRS parameters during simple walking and during dual task in healthy subjects and in stroke patients.
A fNIRS system will be used to measure the CPF activation. The subjects will walk at their preferred speed on 10 m 3 times and while doing a cognitive task (dual task) 3 times also (in a random order). The same test will be repeated five minutes later. The fNIRS system will be retired and the same test will be repeated 10 min later.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Functional Near-Infrared Spectroscopy (fNIRS) acquisitions | Experimental | The hemodynamic response in CPF will be measured using an Octomon+ system (Artinis). Eight emission and two detector probes will be arranged on the participant's forehead. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Functional Near-Infrared Spectroscopy (fNIRS) | Procedure | All participants will undergo Functional Near-Infrared Spectroscopy (fNIRS). The hemodynamic response in CPF will be measured using an Octomon+ system (Artinis). Eight emission and two detector probes will be arranged on the participant's forehead. |
| Measure | Description | Time Frame |
|---|---|---|
| Oxyhemoglobin (HbO) variations during simple walking and during dual task | HbO will be measured by the NIR spectrometry technique continuously at rest and during walking. This technique allows to measure the variations of HbO concentration by measuring the variations of light absorption by the explored tissues. | Day 0 |
| Deoxyhemoglobin (HbR) variations during simple walking and during dual task | HbR will be measured by the NIR spectrometry technique continuously at rest and during walking. This technique allows to measure the variations of HbR concentration by measuring the variations of light absorption by the explored tissues. | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Oxyhemoglobin (HbO) variations of acute stroke patients | Day 0 | |
| Deoxyhemoglobin (HbR) variations of acute stroke patients | Day 0 | |
| Oxyhemoglobin (HbO) variations of subacute stroke patients |
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Inclusion Criteria:
Acute stroke group, subacute stroke group, and control group:
Acute Stroke and Subacute Stroke Group:
Exclusion Criteria:
Acute stroke group, subacute stroke group, and control group:
Acute stroke group and subacute stroke group:
Control group: neurological medical history
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| Name | Affiliation | Role |
|---|---|---|
| Andreea AIGNATOAIE | CHR d'Orléans | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Réadaptation Fonctionnelle et d'Appareillage Le Coteau | La Chapelle-Saint-Mesmin | France | ||||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31312136 | Background | Hermand E, Tapie B, Dupuy O, Fraser S, Compagnat M, Salle JY, Daviet JC, Perrochon A. Prefrontal Cortex Activation During Dual Task With Increasing Cognitive Load in Subacute Stroke Patients: A Pilot Study. Front Aging Neurosci. 2019 Jul 2;11:160. doi: 10.3389/fnagi.2019.00160. eCollection 2019. | |
| 29604488 | Background |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Healthy subjects, acute stroke patients, subacute stroke patients
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|
| Day 0 |
| Deoxyhemoglobin (HbR) variations of subacute stroke patients | Day 0 |
| Oxyhemoglobin (HbO) variations using different mathematical treatments. | Day 0 |
| Deoxyhemoglobin (HbR) variations using different mathematical treatments. | Day 0 |
| Chu Limoges |
| Limoges |
| France |
| CHR Orléans | Orléans | 45067 | France |
| Hawkins KA, Fox EJ, Daly JJ, Rose DK, Christou EA, McGuirk TE, Otzel DM, Butera KA, Chatterjee SA, Clark DJ. Prefrontal over-activation during walking in people with mobility deficits: Interpretation and functional implications. Hum Mov Sci. 2018 Jun;59:46-55. doi: 10.1016/j.humov.2018.03.010. Epub 2018 Mar 29. |
| 6691052 | Background | Holden MK, Gill KM, Magliozzi MR, Nathan J, Piehl-Baker L. Clinical gait assessment in the neurologically impaired. Reliability and meaningfulness. Phys Ther. 1984 Jan;64(1):35-40. doi: 10.1093/ptj/64.1.35. |
| 31110922 | Background | Pelicioni PHS, Tijsma M, Lord SR, Menant J. Prefrontal cortical activation measured by fNIRS during walking: effects of age, disease and secondary task. PeerJ. 2019 May 3;7:e6833. doi: 10.7717/peerj.6833. eCollection 2019. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |