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Acute kidney injury is commonly accompanied major complication after aortic surgery.
Cardipulmonary bypass lyses erythrocyte and induces lipid peroxidation. This increases plasma free hemoglobin, F2-isoprostane, and isofuran concentration. Cell free hemoglobin have been reported to be associated with poor prognosis such as acute kidney injury, myocardial infarction, and death.
Acetaminophen is reported to attenuate hemeprotein mediated lipid peroxidation. Thus, investigators hypothesized that acetaminophen might have protective effect on the incidence of acute kidney injury in patients undergoing aortic surgery with moderate hypothermic circulatory arrest.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acetaminophen group | Experimental | patients receiving acetaminophen |
|
| Placebo group | Placebo Comparator | patients receiving equal amount of normal saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acetaminophen | Drug | Acetaminophen 1g IV every 6 hours for a weight > 50kg (maximum of 4g per 24 hours) or 15mg/kg every 6 hours for a weight < 50kg (maximum of 75mg/kg per 24 hours) |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of acute kidney injury after aortic surgery with moderate hypothermic circulatory arrest | Compare the incidence of acute kidney injury within 7 days after surgery. Acute kidney injury is defined using KDIGO criteria. | Postoperative 7 days |
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Inclusion Criteria:
1) Patients undergoing aortic surgery with moderate hypothermic circulatory arrest.
Exclusion Criteria:
3) patients taking acetaminophen or diclofenac 4) patients who cannot understand informed consent
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| SungYeon Ham | Contact | 82-2-2019-4601 | SYID0424@yuhs.ac |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gangnam Severance Hospital | Recruiting | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24732290 | Background | Simpson SA, Zaccagni H, Bichell DP, Christian KG, Mettler BA, Donahue BS, Roberts LJ 2nd, Pretorius M. Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass. Pediatr Crit Care Med. 2014 Jul;15(6):503-10. doi: 10.1097/PCC.0000000000000149. |
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| ID | Term |
|---|---|
| D000082 | Acetaminophen |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| Placebo | Other | Normal saline 100 ml (equal amount of acetaminophen) IV every 6 hours |
|
| Aniline Compounds |
| D000588 | Amines |