The purpose of this study is to find out whether using the PINPOINT imaging system intra-operatively can reduce the risk of anastomotic leaks and other complications after surgery for ovarian cancer, compared with standard intra-operative assessments alone. The PINPOINT endoscopic fluorescence imaging system uses a special camera and a fluorescent (glowing) dye that can evaluate the blood flow of the bowel in real-time. If there is an area that appears concerning, the surgeon can correct the problem during the procedure.

Participant Inclusion Criteria

Part 1 (pre-operative):

• 18 years or older
• Diagnosed with primary or recurrent ovarian, fallopian tube, or primary peritoneal cancer
• Scheduled to undergo debulking or cytoreductive surgery
• Suspected need for a low anterior rectosigmoid resection at the time of a debulking procedure
• Enrolled and consented before the operation

Part 2 (intra-operative):

• Completed rectosigmoid resection
• Surgeon plans to perform colorectal anastomosis

Participant Exclusion Criteria

Part 1 (pre-operative):

• Documented history of allergic reaction to ICG
• Not approached for study enrollment before undergoing an unexpected low anterior rectosigmoid resection

Part 2 (intra-operative):

• Did not undergo rectosigmoid resection intraoperatively
• Surgical procedure with rectosigmoid resection for any other type of gynecologic malignancy
• Patient requires permanent colostomy

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.