Effects of Topical Insulin on Levels of Tear Inflammatory Mediators

Effects of Topical Insulin on Levels of Tear Inflammatory Mediators Compared to Standard Artificial Tears and Normal Saline in Diabetics With Dry Eye Disease

60 samples are take to determine the effects of topical insulin on tear inflammatory mediators interleukin 1a, interleukin 6 and matrix metalloprotenase 9 in diabetics with dry eye disease.

Tear samples are taken to compare the levels of inflammatory markers (IL 1a, IL6 and MMP 9) pre-and post treatment with topical insulin in normal saline compared to standard therapy and normal saline in diabetics with dry eyes and also to correlate the IL 1a, IL6 and MMP 9 levels with clinical outcomes in diabetics with dry eyes treated with topical insulin in normal saline, standard therapy and normal saline

Inclusion Criteria:

• all diabetics aged 18 - 50 years of age with at least mild OSDI scores

Exclusion Criteria:

• Diabetics on contact lenses
• Diabetic with history of ocular surgery in the preceding 3 months
• Post menopausal women
• Known mild dry eye with prior usage of topical therapy who are unable to discontinue
• Known case of allergic eye disease
• Sjogren's syndrome patients
• Unwilling or unable to attend 6 follow up and sampling sessions