The main objective of this prospective cohort study is to assess arrhythmia burden and glycemic variability in a multicenter cohort of patients with end-stage renal disease using a sufficient observation period in order to identify arrhythmia burden and type and characterize associations with patient characteristics and dialysis treatment, glycemic variability and subsequent risk of adverse outcomes.

Background: The risk of dying of a cardiovascular disease is 10-20 times increased in patients dependent on dialysis treatment compared to the general population. 1/3 of these deaths is caused by arrhythmia and 'sudden cardiac death'.

Purpose: Investigate the prevalence and type of arrhythmia in patients dependent on dialysis treatment, including the association with patient- and dialysis related factors and cardiovascular outcomes.

Methods: 7-days Holter-monitoring with Cortrium C3+ holter-monitor in 540 patients dependent on dialysis treatment in the Capital Region of Denmark. Continous blood glucose monitoring in a subgroup. 1-year follow-up via national registers.

Endpoints:

• Prevalence of atrial fibrillation
• Prevalence of other arrhythmia (tachycardia, bradycardia, AV-block)
• Follow-up outcomes: sudden cardiac death, cardiovascular disease and cardiovascular death

Inclusion Criteria:

• Dialysis-treated end-stage renal disease
• Age ≥ 18 years
• Competence to understand the study rationale necessary for written informed consent

Exclusion Criteria:

• Pre-existing pacemaker implantation

Patients with dialysis-treated end-stage renal disease over the age of 18 and without pacemaker implantation.

Tabulated study data and protocols will be made available (within limitations of Danish legislation related to GDPR)

within 1 year of study completion

Data access will be available upon approval via Statistics Denmark