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| Name | Class |
|---|---|
| Marigot Ltd. | INDUSTRY |
| Enterprise Ireland | OTHER_GOV |
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This study aims to inform of the mechanism of action of plant-based protein by measuring the bioavailability (i.e. rate of appearance and magnitude of concentration in the circulation following oral ingestion) of key amino acid and metabolic products that regulate skeletal muscle protein synthesis (MPS) in humans.
Plant-based proteins contain several amino acids that are essential to signal muscle growth/repair and act as a substrate during muscle protein synthesis. However, compared to animal protein or free-amino acids, the bioavailability of certain essential amino acids may be compromised. Following selective processing (e.g. removal of carbohydrate and/or other anti-nutritive factors) food grade plant-based protein concentrates possibly confer greater bioavailability and bioactivity in vivo. This project explores the bioavailability and bioactivity of selected plant-based protein concentrates following oral ingestion in young, healthy men and women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pea-protein concentrate | Experimental | Pea-protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water. |
|
| Fava-bean protein concentrate | Experimental | Fava-bean protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water. |
|
| Chickpea protein concentrate | Experimental | Chickpea protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water. |
|
| Red lentil protein concentrate | Experimental | Red lentil protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water. |
|
| Non-essential amino acid blend | Experimental | Non-essential amino acid blend dosed at 0.33 g/kg body mass in 500 ml of water. |
|
| Whey protein concentrate |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pea-protein concentrate | Dietary Supplement | Pea-protein concentrate |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma amino acids | Plasma amino acids measured by HPLC | 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
Healthy young men
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| Name | Affiliation | Role |
|---|---|---|
| Phil Jakeman, PhD | University of Limerick | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Education and Health Sciences | Limerick | V94 T9PX | Ireland |
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Subjects who volunteer for this study will undertake SIX controlled feeding trials, each trial separated by 7 days.Subjects will be assigned to a randomised sequence of six protein isolates including: (1) pea-protein concentrate; (2) fava-bean protein concentrate; (3) chickpea protein concentrate; (4) red lentil protein concentrate; (5) non-essential amino acid blend (negative control);( 6) whey protein concentrate. Protein is dosed at 0.33 g/kg body mass in 500 ml of water.
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| Experimental |
Whey protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water. |
|
| Fava-bean protein concentrate |
| Dietary Supplement |
Fava-bean protein concentrate |
|
| Chickpea protein concentrate | Dietary Supplement | Chickpea protein concentrate |
|
| Red lentil protein concentrate | Dietary Supplement | Red lentil protein concentrate |
|
| Non-essential amino acid blend | Dietary Supplement | Non-essential amino acid blend |
|
| Whey protein concentrate | Dietary Supplement | Whey protein concentrate |
|
| ID | Term |
|---|---|
| D000067796 | Whey |
| ID | Term |
|---|---|
| D008892 | Milk |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003611 | Dairy Products |
| D005502 | Food |
| D019602 | Food and Beverages |
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