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Pain control is a critical after many surgical procedures. It is well known that orthopaedic surgeries are among the most painful procedures, with total joint arthroplasty being a clear example of this situation. Current trends in pain management are morphing and multimodal opioid sparing protocols are now being evaluated and implemented, with results showing a decrease in the amount of opioids being prescribed. Despite all efforts, most patients experience pain and, in order to control it, multiple medications have been tried with variable results. The most commonly prescribed medications are opioids, but side effects associated with their use as well as their addictive potential are making them a less desirable option for patients. Currently there is a trend towards diminishing opioids consumption and prescribing alternative pain control regimens.Caffeine is a well known molecule that when associated with non-steroidal anti-inflammatory drugs (NSAIDS) potentiates their analgesic effect and decreases the amount of doses required to control pain. Little is known about the effect of caffeine over pain relief in patients undergoing total joint arthroplasty, but preliminary results in other fields make us believe it could have a potential benefit for patients undergoing total joint arthroplasty.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Caffeine Group | Active Comparator | 2 week supply of 100mg caffeine + aspirin 325mg + standard pain regimen (experimental) |
|
| No Caffeine Group | Active Comparator | aspirin 325mg + standard pain (control) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Total Shoulder Arthroplasty | Procedure | Participant will have total shoulder replacement |
|
| Measure | Description | Time Frame |
|---|---|---|
| postoperative shoulder function | This will be measured using the Simple Shoulder Test (SST) which consist of 12 questions | 24 weeks |
| Postoperative shoulder function | This will be measured using the American Shoulder and Elbow Surgeon Survey (ASES) | 24 weeks |
| Postoperative Pain | This will be measured using the Visual Analog Scale for Pain (VAS) survey | 15 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rothman Orthopaedic Institute | Philadelphia | Pennsylvania | 19107 | United States |
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| ID | Term |
|---|---|
| D018771 | Arthralgia |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D000072228 | Arthroplasty, Replacement, Shoulder |
| D002110 | Caffeine |
| C514822 | oxycodone-acetaminophen |
| D017294 | Ondansetron |
| D013607 | Tablets |
| ID | Term |
|---|---|
| D019643 | Arthroplasty, Replacement |
| D001178 | Arthroplasty |
| D019637 | Orthopedic Procedures |
| D013514 | Surgical Procedures, Operative |
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| Caffeine Pill | Drug | 2 week supply of 1000 mg caffeine given postoperatively as part of the pain regimen |
|
| Percocet 10Mg-325Mg Tablet | Drug | given postoperatively as standard post-op pain management |
|
| Zofran 4Mg Tablet | Drug | given postoperatively as standard post-op management |
|
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019651 | Plastic Surgery Procedures |
| D019919 | Prosthesis Implantation |
| D014970 | Xanthines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011688 | Purinones |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D002227 | Carbazoles |
| D007211 | Indoles |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |