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| Name | Class |
|---|---|
| Gilead Sciences | INDUSTRY |
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Radiological and lung function recovery following Covid-19 infection.
The investigators propose to conduct pulmonary LDCT imaging and physiological lung function assessments, and combine this with detailed multi-regional hospitalization clinical data collection on COVID-19 cases (COREG registry); to inform long-term pulmonary and extra-pulmonary consequences and the recovery trajectory following COVID-19 infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Moderate to severe COVID-19 infection | COVID-19 patients with radiographic changes on CXR or CT which had not resolved or had persistent hypoxia due to COVID-19 at the time of discharge will be enrolled. All participants will undergo a LDCT and PFT. |
| |
| Persistent LDCT or PFT abnormalities | Participants with abnormalities on LDCT and or PFT will be invited to continue with a follow-up sub-study. This will involve follow up with repeated LDCT and PFT at subsequent time points to monitor and manage the abnormalities detected until the abnormalities fully resolve or to the last time point at 9 months of the study. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CT scan | Diagnostic Test | Non-enhanced LDCT scans of the thorax will be taken using standard technology on helical CT system |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary changes on LDCT Scan | Identify pulmonary changes utilizing LDCT chest to characterize the pulmonary recovery trajectory of survivors of COVID-19. | Through study completion, an average of 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| DLCO | Identify DLCO changes over time to characterize the pulmonary recovery trajectory of survivors of COVID-19. | Through study completion, an average of 9 months |
| TLC | Identify TLC changes over time to characterize the pulmonary recovery trajectory of survivors of COVID-19. |
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Inclusion Criteria:
Exclusion Criteria:
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COVID-19 patients discharged from hospitals with radiographic and clinical evidence of COVID-19 pneumonia during hospitalization.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mylinh Duong, MD | Contact | 905 525-9140 | duongmy@mcmaster.ca |
| Name | Affiliation | Role |
|---|---|---|
| Mylinh Duong, MD | McMaster University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Juravinski Hospital | Recruiting | Hamilton | Ontario | L8V 1C3 | Canada |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D014057 | Tomography, X-Ray Computed |
| D012129 | Respiratory Function Tests |
| ID | Term |
|---|---|
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Pulmonary Function Test | Diagnostic Test | Standard pulmonary function testing will be conducted by trained pulmonary technologists following the American Thoracic Society standards |
|
| Through study completion, an average of 9 months |
| FEV1 | Identify FEV1 changes over time to characterize the pulmonary recovery trajectory of survivors of COVID-19. | Through study completion, an average of 9 months |
| FVC | Identify FVC changes over time to characterize the pulmonary recovery trajectory of survivors of COVID-19. | Through study completion, an average of 9 months |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D014054 | Tomography |
| D003948 | Diagnostic Techniques, Respiratory System |