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Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections.
Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections. The study enrolled patients admitted to the Emergency Center of Vojvodina with the diagnosis of multispace DNI with or without DNM either as the primary diagnosis or with discharged diagnosis after surgical treatment during 7-years period. The data were obtained from patient medical records.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DNI group | patients with infection of two or more deep neck spaces (DNI group) |
| |
| DNI + DNM group | patients with infection of two or more deep neck spaces with secondary descending necrotizing mediastinitis (DNI + DNM group) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| treatment of infection | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of mediastinitis | Neck and chest computed tomography (CT) | Within 6 hours of admission |
| Measure | Description | Time Frame |
|---|---|---|
| Microbiological findings in DNI and DNM | Prevalence of microorganisms in mediastinitis | Within 1 week of admission |
| Average number of hospital days | Comparison of average number of hospital days in DNI and DNM |
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Inclusion Criteria:
Exclusion Criteria:
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This study enrolled patients admitted to the Emergency Center of Vojvodina with the diagnosis of multispace DNI with or without DNM either as the primary diagnosis or with discharged diagnosis after surgical treatment.
The diagnosis of DNM was based on standard Estrera et al. diagnostic criteria. Cases included in the study comprised patients admitted to the hospital due to DNI affecting two or more spaces with or without DNM. Cases were excluded from the study if complete medical data could not be obtained from medical charts.
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| Name | Affiliation | Role |
|---|---|---|
| Aleksandar Kiralj, PhD | Clinical Center of Vojvodina | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26829352 | Result | Prado-Calleros HM, Jimenez-Fuentes E, Jimenez-Escobar I. Descending necrotizing mediastinitis: Systematic review on its treatment in the last 6 years, 75 years after its description. Head Neck. 2016 Apr;38 Suppl 1:E2275-83. doi: 10.1002/hed.24183. Epub 2016 Feb 1. | |
| 31862339 | Result | Qu L, Xu H, Liang X, Cai X, Zhang W, Qian W. A Retrospective Cohort Study of Risk Factors for Descending Necrotizing Mediastinitis Caused by Multispace Infection in the Maxillofacial Region. J Oral Maxillofac Surg. 2020 Mar;78(3):386-393. doi: 10.1016/j.joms.2019.11.017. Epub 2019 Nov 26. |
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| ID | Term |
|---|---|
| D007239 | Infections |
| D008480 | Mediastinitis |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D008477 | Mediastinal Diseases |
| D013896 | Thoracic Diseases |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
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| Through study completion, an average of one month |
| Incidence of complications | Complications among DNI and DNI+DNM groups | Within 30 days from admission |
| Number of infected deep neck spaces | Neck and chest computed tomography (CT) | Within 6 hours of admission |
| 21820786 | Result | Sarna T, Sengupta T, Miloro M, Kolokythas A. Cervical necrotizing fasciitis with descending mediastinitis: literature review and case report. J Oral Maxillofac Surg. 2012 Jun;70(6):1342-50. doi: 10.1016/j.joms.2011.05.007. Epub 2011 Aug 6. |
| 18952475 | Result | Boscolo-Rizzo P, Da Mosto MC. Submandibular space infection: a potentially lethal infection. Int J Infect Dis. 2009 May;13(3):327-33. doi: 10.1016/j.ijid.2008.07.007. Epub 2008 Oct 25. |
| 31747058 | Result | Kimura A, Miyamoto S, Yamashita T. Clinical predictors of descending necrotizing mediastinitis after deep neck infections. Laryngoscope. 2020 Nov;130(11):E567-E572. doi: 10.1002/lary.28406. Epub 2019 Nov 20. |
| 34542654 | Derived | Brajkovic D, Zjalic S, Kiralj A. Prognostic factors for descending necrotizing mediastinitis development in deep space neck infections-a retrospective study. Eur Arch Otorhinolaryngol. 2022 May;279(5):2641-2649. doi: 10.1007/s00405-021-07081-0. Epub 2021 Sep 20. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |