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The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Breathing intervention | Experimental | Participants will complete 2-minute breathing exercises following the Breathing App every 15 minutes during a 4-hour postprandial period following high-fat meal consumption. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal physiologic rate breathing | Behavioral | 2-minute breathing exercises will be completed every 15 minutes. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in flow-mediated dilation | Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation. | At baseline and at again 1, 2, 4 hours post high-fat meal consumption |
| Changes in oxidative stress | Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress. | Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption. |
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Inclusion Criteria:
• Male participants ages 18-35 years
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular Physiology Laboratory-Texas State University | San Marcos | Texas | 78666 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36344308 | Derived | Hunter SD, Bernardi L, McAllister MJ, John D, Rahimi M, Lopez MR. Device-guided slow breathing alters postprandial oxidative stress in young adult males: A randomized sham-controlled crossover trial. Nutr Metab Cardiovasc Dis. 2023 Jan;33(1):203-209. doi: 10.1016/j.numecd.2022.10.002. Epub 2022 Oct 10. |
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| ID | Term |
|---|---|
| D053120 | Respiratory Aspiration |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Each participant will complete 2 different sessions in random order.
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Participants will be blinded to the respiratory rates being practiced during each study visit. Breathing patterns will be completed in random order.
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| Slow breathing | Behavioral | 2-minute breathing exercises will be completed every 15 minutes. |
|