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The COVID-19 epidemic has now raged for more than a year with more than 100 million identified cases and nearly 2.5 million deaths worldwide. Since November 2020, we have been witnessing the emergence of viral variants in different regions of the world. This expected genetic drift of the virus, but somewhat abrupt since November, raises questions concerning the characteristics of transmissibility, pathogenicity, sensitivity to possible treatments, and escape from natural or vaccine immunity. The objective of this study is to find out whether the new variants of SARS-CoV-2 are associated with particular clinical forms. The results of this research will provide elements to determine whether the new variants of SARS-CoV-2 are associated with more severe clinical forms.
SEVASAR is a paired cohort study with retrospective data collection:
The severity of illness will be compared between pairs. Disease severity will be assessed according to the following definition: defined by a composite criterion including, at 28 days after hospital admission: WHO scale >5 /11 levels, (death OR need for invasive ventilation OR need for high flow ventilation (Optiflex or NIV or CPAP) or high concentration mask. This event will be taken into account regardless of its time of occurrence between the first day of the hospitalization studied and D29 after hospital admission.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exposed | Patients hospitalized for COVID-19 with SARS-CoV-2 variant 20I / 501Y.V1 |
| |
| Non exposed | Patients hospitalized for COVID-19 to SARS-CoV-2 corresponding to wild type 20A variants. EU1 or 20A. EU2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Data collection | Other | Data collection |
|
| Measure | Description | Time Frame |
|---|---|---|
| To estimate the proportion of Severe disease form | Percentage of severe form. Severity was defined by a composite criterion including, at Day 28 days from hospital admission: WHO scale >5 /11 levels, (death OR required invasive ventilation OR required high flow ventilation (Optiflex or NIV or CPAP) or high concentration mask. | between the first day of hospitalization and Day 29 |
| To estimate the proportion of Mortality | Percentage of mortality | Day 29 |
| To estimate the proportion of WHO score > 5 | Percentage of WHO score > 5 | between the first day of hospitalization and Day 29 |
| To estimate the proportion of Patient who received critical care | Percentage of patients who received critical care | between the first day of hospitalization and Day 29 |
| To estimate the proportion of patients who had invasive ventilation | Percentage of patients who had invasive ventilation | between the first day of hospitalization and Day 29 |
| To estimate the proportion of patients who had high flow oxygen therapy | Percentage of patients who had high flow oxygen therapy | between the first day of hospitalization and Day 29 |
| Time between the first day of symptoms and the first day of hospitalization | Time between the first day of symptoms and the first day of hospitalization |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with Acute symptomatic COVID PCR+ with screening Hospitalized for acute COVID between January 1,2021 (or since the implementation of the screening in the center) and february 28, 2021
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xavier Lescure, Pr | Contact | 0140258080 | xavier.lescure@aphp.fr | |
| Guillaume Martin-Blondel, Pr | Contact | 0561779699 | martin-blondel.g@chu-toulouse.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens Picardie Site Nord | Recruiting | Amiens | 80000 | France |
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| between first day of symptoms and the first day of hospitalization assessed up to one month |
| Delay between the first day of symptoms and the first day of hospitalization | Time between the first day of symptoms and the first day of hospitalization | between first day of symptoms and the first day of hospitalization assessed up to one month |
| Time between the first day of symptoms and the severity of disease | Time between the first day of symptoms and the severity of disease | between first day of symptoms and the severity assessed up to one month |
| Time between the first day of symptoms and mortality | Time between the first day of symptoms and mortality | between first day of symptoms and mortality assessed up to two month |
| CHU Angers | Recruiting | Angers | France |
|
| Centre hospitalier de Béziers | Recruiting | Béziers | 34 500 | France |
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| hôpital Avicenne | Recruiting | Bobigny | 93000 | France |
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| Hôpital Pellegrin | Recruiting | Bordeaux | 33075 | France |
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| Hôpital Ambroise Paré | Recruiting | Boulogne-Billancourt | 92104 | France |
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| Centre hospitalier métropole Savoie | Recruiting | Chambéry | 73011 | France |
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| Centre Hospitalier Châteaubriant Nozay Pouancé | Recruiting | Châteaubriant | 44 110 | France |
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| Hôpital Beaujon | Recruiting | Clichy | 92110 | France |
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| Hôpitaux Civils de Colmar | Recruiting | Colmar | 68000 | France |
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| Centre Hospitalier Alpes Léman | Recruiting | Contamine-sur-Arve | 74130 | France |
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| Centre hopsitalier Sud Francilien | Recruiting | Corbeil-Essonnes | 91106 | France |
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| Centre Hospitalier Intercommunal | Recruiting | Créteil | 94 000 | France |
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| Hôpital Henry Mondor | Recruiting | Créteil | 94000 | France |
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| CHU Dijon Bourgogne | Recruiting | Dijon | 21079 | France |
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| Hôpital de Garches | Recruiting | Garches | 92380 | France |
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| Hôpital Kremlin Bicêtre | Not yet recruiting | Le Kremlin-Bicêtre | 94270 | France |
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| Hôpital SALENGRO | Recruiting | Lille | 59000 | France |
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| CHU Limoges | Recruiting | Limoges | 87100 | France |
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| Hospices Civils de Lyon | Recruiting | Lyon | 69004 | France |
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| Centre Hospitalier François Quesnay | Recruiting | Mantes-la-Jolie | 78200 | France |
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| Hôpital André Grégoire | Recruiting | Montreuil | 93100 | France |
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| Hopital Confluent | Recruiting | Nantes | 44 000 | France |
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| CHU Nantes | Recruiting | Nantes | France |
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| American Hospital of Paris | Recruiting | Neuilly-sur-Seine | 92 200 | France |
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| Hôpital Archet | Recruiting | Nice | France |
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| Hôpital Carémeau | Recruiting | Nîmes | 30029 | France |
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| Centre Hospitalier du Centre-Bretagne | Recruiting | Noyal-Pontivy | 56920 | France |
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| Groupe Hospitalier Diaconesses Croix Saint-Simon | Recruiting | Paris | 75 012 | France |
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| HôpitalSaint Antoine | Recruiting | Paris | 75012 | France |
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| hôpital Cochin | Not yet recruiting | Paris | 75014 | France |
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| Hôpital Necker | Recruiting | Paris | 75015 | France |
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| Hôpital Bichat | Recruiting | Paris | 75019 | France |
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| Hôpital Tenon | Recruiting | Paris | 75020 | France |
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| Hôpital Saint Louis | Recruiting | Paris | 75475 | France |
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| Centre hospitalier de Perigueux | Recruiting | Périgueux | 24 019 | France |
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| CHI de Poissy/Saint-Germain-en-Laye | Not yet recruiting | Poissy | 78300 | France |
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| CHU | Not yet recruiting | Reims | 51092 | France |
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| Hôpital Pontchaillou | Recruiting | Rennes | 35033 | France |
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| Hôpital Charles Nicoll | Recruiting | Rouen | 76038 | France |
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| Hôpital d'Instruction des Armées Bégin | Not yet recruiting | Saint-Mandé | 94160 | France |
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| Nouvel Hopital Civil | Recruiting | Strasbourg | 67000 | France |
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| Hôpital Foch | Recruiting | Suresnes | 92150 | France |
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| Hôpital Purpan | Recruiting | Toulouse | 31300 | France |
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| Centre hospitalier de Tourcoing | Recruiting | Tourcoing | 59200 | France |
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| CHU Tours | Recruiting | Tours | France |
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| Centre Hospitalier de Valence | Recruiting | Valence | 26 000 | France |
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| Centre hospitalier de Valenciennes | Recruiting | Valenciennes | 59 300 | France |
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| CHRU Nancy Brabois | Recruiting | Vandœuvre-lès-Nancy | 54511 | France |
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| Centre Hospitalier Bretagne Atlantique | Recruiting | Vannes | 56 000 | France |
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| Institut Gustave Roussy | Recruiting | Villejuif | 94805 | France |
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| Centre Hospitalier Intercommunal | Recruiting | Villeneuve-Saint-Georges | 94190 | France |
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| André Zobda Cabié | Recruiting | Fort-de-France | Martinique France | 97200 | Martinique |
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| ID | Term |
|---|---|
| D003625 | Data Collection |
| ID | Term |
|---|---|
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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