The aim of this study is to compare the quality of life in subjects with benign and malignant biliary obstruction who have or will undergo endoscopic retrograde cholangiopancreatography (ERCP) and/or percutaneous trans-hepatic biliary drainage (PTBD).

Inclusion Criteria:

• Patients with benign biliary obstruction
• Patients with malignant biliary obstruction
• Patients undergoing ERCP and/or PTBD

Exclusion Criteria:

• Patients with gallstone disease
• Patients who will undergo ERCP who have previously underwent a PTBD
• Patients who will undergo PTBD who have previously underwent an ERCP
• Female patients who are pregnant
• Prisoners and other vulnerable populations

Adult patients aged 18 or over with a diagnosis of benign or malignant biliary obstruction who have underwent an ERCP and/or PTBD will be identified through Best Practices Advisory (BPA), referrals from the clinics of GI consultants and the gastroenterology department procedure schedules at Mayo Clinic, Rochester.