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| Name | Class |
|---|---|
| Budapest University of Technology and Economics | OTHER |
| Hochschule Furtwangen University | OTHER |
| Szeged University | OTHER |
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Apnea testing is the final decisive examination in the strictly regulated process of brain death assessment. There is no standardized method found in the literature for apnea testing except for the inspection of possible spontaneous chest movements. In addition, the test itself lasts for several minutes leading to the collapse of the lungs.
Electrical impedance tomography (EIT) is a non-invasive, real-time monitoring technique, which is suitable for detecting changes in lung volumes during ventilation. With its help, one can examine the spontaneous initiation of inspiration, the development of atelectasis and the reopening of collapsed regions by mechanical ventilation.
Furthermore, the apnea test provides for analysing the effect of changes in pulmonary perfusion on impedance in the absence of noise generated by ventilation.
The aim of the study is to assess the eligibility of electrical impedance monitoring for the detection of possible spontaneous initiations of inspiration during apnea test in patients with suspected brain death. The study could contribute to the opening of new areas in the clinical use of the electrical impedance device. An additional aim is to observe the collapse and the reopening by recruitment manoeuvers of different pulmonary regions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| apnea test, recruitment manoeuvre | Experimental |
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Apnea test, alveolar recruitment | Diagnostic Test | Alveolar recruitment following the phase of apnea testing |
|
| Measure | Description | Time Frame |
|---|---|---|
| detection of spontaneous inspiration | Detection of absolute changes in impedance using EIT during apnea test, which may refer to spontaneous initiations of inspiration | 20 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Gas exchange | Change in arterial partial pressure of oxygen (PaO2) (mmHg) following alveolar recruitment performed after apnea testing | 20 minutes |
| Dynamic compliance | Change in dynamic compliance (ml/cmH2O) following alveolar recruitment |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Szeged | Szeged | 6725 | Hungary |
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| ID | Term |
|---|---|
| D001926 | Brain Death |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D003128 | Coma |
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| 20 minutes |
| End expiratory lung impedance | Change in end expiratory lung impedance (EELI) (%) following alveolar recruitment | 20 minutes |
| Center of ventilation | Change in center of ventilation (%) following alveolar recruitment | 20 minutes |
| Lung perfusion | Changes in lung perfusion during the apnea phase (%) | 20 minutes |
| D014474 |
| Unconsciousness |
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D003643 | Death |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |