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| Name | Class |
|---|---|
| Hospital Civil de Guadalajara | OTHER |
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The primary objective of this study is to explore the physiological mechanism of awake, self proning among patients with acute hypoxemic respiratory failure induced by COVID-19, using LUS in the first three days and explore the predictive value of LUS in patients' outcome.
Lung ultrasound (LUS) has recently gained popularity among the imaging methods to perform bedside assessment of critically ill patients to guide clinical management. LUS is a non-invasive and easy-to-perform procedure that provides precise data on lung aeration, lung recruitment, lung morphology, and lung perfusion. Studies have shown that LUS is a useful tool in monitoring lung reaeration in intubated patients diagnosed with traditional ARDS undergoing prone positioning; however there are mixed findings in terms of the use of LUS in predicting potential prone positioning response. A recent study found that the non-intubated COVID-19 patients who responded to prone positioning had more pronounced disturbances of aeration in posterior regions, however, they only investigated patients' response to the first prone positioning and the information for the patients' outcome is lacking. In our previous study with intubated COVID-19 patients, we found that patients' response to the subsequent prone positioning had higher predictive value than the response to the first prone positioning. Therefore, the primary objective of this study is to explore the physiological mechanism of awake, self proning among patients with acute hypoxemic respiratory failure induced by COVID-19, using LUS in the first three days and explore the predictive value of LUS in patients' outcome.
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| Measure | Description | Time Frame |
|---|---|---|
| SpO2/FiO2 pre prone in day 1 | Patients' response of oxygenation using SpO2/FiO2 | pre prone in day 1 |
| SpO2/FiO2 post prone in day 1 | Patients' response of oxygenation using SpO2/FiO2 | post prone in day 1 |
| SpO2/FiO2 pre prone in day 2 | Patients' response of oxygenation using SpO2/FiO2 | Pre prone in day 2 |
| SpO2/FiO2 post prone in day 2 | Patients' response of oxygenation using SpO2/FiO2 | Post prone in day 2 |
| SpO2/FiO2 pre prone in day 3 | Patients' response of oxygenation using SpO2/FiO2 | Pre prone in day 3 |
| SpO2/FiO2 post prone in day 3 | Patients' response of oxygenation using SpO2/FiO2 | Post prone in day 3 |
| Lung Ultrasound Score pre prone in day 1 | Patients' response of oxygenation using Lung ultrasound score | Pre prone in day 1 |
| Lung Ultrasound Score post prone in day 1 | Patients' response of oxygenation using Lung ultrasound score | Post prone in day 1 |
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Inclusion Criteria:
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Adult patients with acute hypoxemic respiratory failure due to COVID-19 who are admitted at Rush University Medical Center
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| Name | Affiliation | Role |
|---|---|---|
| Jie Li | Rush University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rush University Medical Center | Chicago | Illinois | 60612 | United States | ||
| Hospital Civil Fray Antonio Alcalde |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33823862 | Background | Langer T, Brioni M, Guzzardella A, Carlesso E, Cabrini L, Castelli G, Dalla Corte F, De Robertis E, Favarato M, Forastieri A, Forlini C, Girardis M, Grieco DL, Mirabella L, Noseda V, Previtali P, Protti A, Rona R, Tardini F, Tonetti T, Zannoni F, Antonelli M, Foti G, Ranieri M, Pesenti A, Fumagalli R, Grasselli G; PRONA-COVID Group. Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients. Crit Care. 2021 Apr 6;25(1):128. doi: 10.1186/s13054-021-03552-2. | |
| 27899151 |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Lung Ultrasound Score pre prone in day 2 | Patients' response of oxygenation using Lung ultrasound score | Pre prone in day 2 |
| Lung Ultrasound Score post prone in day 2 | Patients' response of oxygenation using Lung ultrasound score | Post prone in day 2 |
| Lung Ultrasound Score pre prone in day 3 | Patients' response of oxygenation using Lung ultrasound score | Pre prone in day 3 |
| Lung Ultrasound Score post prone in day 3 | Patients' response of oxygenation using Lung ultrasound score | Post prone in day 3 |
| Guadalajara |
| Jalisco |
| 44280 |
| Mexico |
| Background |
| Wang XT, Ding X, Zhang HM, Chen H, Su LX, Liu DW; Chinese Critical Ultrasound Study Group (CCUSG). Lung ultrasound can be used to predict the potential of prone positioning and assess prognosis in patients with acute respiratory distress syndrome. Crit Care. 2016 Nov 30;20(1):385. doi: 10.1186/s13054-016-1558-0. |
| 33494771 | Background | Avdeev SN, Nekludova GV, Trushenko NV, Tsareva NA, Yaroshetskiy AI, Kosanovic D. Lung ultrasound can predict response to the prone position in awake non-intubated patients with COVID-19 associated acute respiratory distress syndrome. Crit Care. 2021 Jan 25;25(1):35. doi: 10.1186/s13054-021-03472-1. No abstract available. |
| 33158500 | Result | Weiss TT, Cerda F, Scott JB, Kaur R, Sungurlu S, Mirza SH, Alolaiwat AA, Kaur R, Augustynovich AE, Li J. Prone positioning for patients intubated for severe acute respiratory distress syndrome (ARDS) secondary to COVID-19: a retrospective observational cohort study. Br J Anaesth. 2021 Jan;126(1):48-55. doi: 10.1016/j.bja.2020.09.042. Epub 2020 Oct 10. |
| 35761404 | Derived | Ibarra-Estrada M, Gamero-Rodriguez MJ, Garcia-de-Acilu M, Roca O, Sandoval-Plascencia L, Aguirre-Avalos G, Garcia-Salcido R, Aguirre-Diaz SA, Vines DL, Mirza S, Kaur R, Weiss T, Guerin C, Li J. Lung ultrasound response to awake prone positioning predicts the need for intubation in patients with COVID-19 induced acute hypoxemic respiratory failure: an observational study. Crit Care. 2022 Jun 27;26(1):189. doi: 10.1186/s13054-022-04064-3. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |