Protein Turnover in Preterm Infants - Feeding of Target Fortified Breast Milk With Different Macronutrient Composition to Improve Growth

Protein Turnover in Preterm Infants - Feeding of Target Fortified Breast Milk With Different Carbohydrate and Fat Composition to Improve Growth

The purpose of this study is to measure protein turnover rates in preterm infants.

After being informed about the study and potential risks, all parents giving written informed consent the principal investigator will determine the eligibility for study entry. Patients who met the eligibility requirements will be randomized in a double-blind manner in a 1:1 ratio to fortified breast milk with higher fat composition to fortified breast milk with higher carbohydrate composition. Both groups will receive a stable protein composition. The participants will receive the intervention for 3 consecutive weeks.

Inclusion Criteria:

• Gestational age < 32 weeks
• Enteral nutrition >150 mL / kg / d

Exclusion Criteria:

• gastrointestinal malformations
• Enterostoma
• short bowel syndrome
• necrotizing enterocolitis
• kidney disease
• Foreseeable transfer