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In this study we will prospectively examine the safety and clinical effects of ultrasound-guided cervical medial branch blocks.
While several clinical trials have found that ultrasound guidance provides similar accuracy to fluoroscopy and reduces performance times for cervical medial branch blocks, larger studies documenting safety-related outcomes are lacking. In addition, although cervical medial branch blocks are an accepted tool to diagnose neck pain originating from the cervical facets, there are reports of long-lasting analgesic effects in a subset of patients, suggesting that these blocks may have long-term benefits. We therefore propose to prospectively examine the incidence of adverse events, as well as the clinical long-term effects of ultrasound-guided cervical medial branch blocks, in a cohort of pain clinic patients undergoing these procedures as part of their usual care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Block | Patients undergoing ultrasound-guided cervical medial branch blocks as part of their usual care |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Block | Procedure | cervical medial branch block |
|
| Measure | Description | Time Frame |
|---|---|---|
| Immediate complications | Proportion of patients with immediate block-related complications including any of the following: vasovagal, local anesthetic toxicity (dizziness, tinnitus, altered LOC, seizure) and trauma to non-targeted neural structures (paresthesia or other neuro symptoms) | Immediately after block |
| Delayed complications | Proportion of patients with delayed block-related complications including any of the following: redness/irritation/swelling at injection site, hematoma, infection, skin bruising, soreness at injection site or increased pain, any neurological symptoms (new onset radicular pain, numbness/weakness or paresthesia in upper extremities). | 14 days after block |
| Measure | Description | Time Frame |
|---|---|---|
| Patient reported pain | Lowest/highest/average pain score over last 7 days (NRS, 11-point scale) | Pre-block, then every 2 weeks for 3 months. |
| NDI | Neck disability index |
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Inclusion Criteria:
Exclusion Criteria:
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Patients presenting to a tertiary outpatient pain clinic for diagnosis and treatment of chronic neck pain
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| Name | Affiliation | Role |
|---|---|---|
| Roderick J Finlayson, MD | University of British Columbia | Principal Investigator |
| John-Paul B Etheridge, MD | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bill Nelems Pain and Research Centre | Kelowna | British Columbia | V1Y 0G1 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40441772 | Derived | Finlayson RJ, Etheridge JB, Godard R, Kaseweter K, Etheridge JP, Curatolo M. Do cervical medial branch blocks have a therapeutic role? a prospective cohort study. Reg Anesth Pain Med. 2025 May 28:rapm-2025-106457. doi: 10.1136/rapm-2025-106457. Online ahead of print. | |
| 38508589 | Derived | Etheridge JB, Finlayson RJ, Venter J, De Villiers F, Etheridge JP, Wakefield R, Watanitanon A. Prospective evaluation of the safety of ultrasound-guided cervical medial branch blocks using the in-plane technique. Reg Anesth Pain Med. 2025 Mar 5;50(3):237-242. doi: 10.1136/rapm-2024-105296. |
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| ID | Term |
|---|---|
| D019547 | Neck Pain |
| D055009 | Spondylosis |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D003766 | Dental Occlusion |
| ID | Term |
|---|---|
| D003813 | Dentistry |
| D009063 | Dental Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
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| Pre-block, then every 2 weeks for 3 months. |
| PHQ-9 | Depression scale | Pre-block then at 1,2 and 3 months post block. |
| GAD-7 | Anxiety scale | Pre-block then at 1,2 and 3 months post block. |
| PCS | Pain catastrophizing scale | Pre-block then at 1,2 and 3 months post block. |
| PGIC | Patient global impression of change 7-point scale | Pre-block, then every 2 weeks for 3 months. |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |