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The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech can detect amyloid-specific cognitive impairment in early stage Alzheimer's disease, based on archival spoken or written language samples, as measured by the AUC of the receiver operating characteristic curve of the binary classifier distinguishing between amyloid positive and amyloid negative arms. Secondary objectives include (1) evaluating how many years before diagnosis of MCI such algorithms work, as measured on binary classifier performance of the classifiers trained to classify MCI vs cognitively normal (CN) arms using archival material from the following time bins before MCI diagnosis: 0-5 years, 5-10 years, 10-15 years, 15-20 years, 20-25 years; (2) evaluating at what age such algorithms can detect later amyloid positivity, as measured on binary classifier performance of the classifiers trained to classify amyloid positive vs amyloid negative arms using archival material from the following age bins: younger than 50, 50-55, 55-60, 65-70, 70-75 years old.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1: MCI amyloid positive |
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| Arm 2: MCI amyloid negative |
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| Arm 3: CN amyloid positive |
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| Arm 4: CN amyloid negative |
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| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome measure is the area under the curve (AUC) of the receiver operating characteristic (ROC) curve of the binary classifier distinguishing between amyloid positive (Arms 1 and 3) and amyloid negative (Arms 2 and 4) arms. | Using archival spoken or written language samples as input. | Up to 85 years |
| Measure | Description | Time Frame |
|---|---|---|
| The sensitivity, specificity and Cohen's kappa of the binary classifier distinguishing between amyloid positive (Arms 1 and 3) and amyloid negative (Arms 2 and 4) arms using archival spoken or written language samples as input. | Up to 85 years | |
| The AUC, sensitivity, specificity and Cohen's kappa of the binary classifiers distinguishing between MCI and cognitively normal (CN) arms. |
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Inclusion Criteria:
(See https://clinicaltrials.gov/ct2/show/NCT04828122)
Exclusion Criteria:
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Participants will be identified from participants of the AMYPRED study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Head of Clinical Operations | Contact | +447849522891 | amypred@novoic.com |
| Name | Affiliation | Role |
|---|---|---|
| Emil Fristed, MSc | Novoic Limited | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Re:Cognition Health | Recruiting | Birmingham | B16 8LT | United Kingdom |
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Using archival spoken or written language samples as input in the following bins: 0-5 years, 5-10 years, 10-15 years, 15-20 years, 20-25 years before MCI diagnosis. |
| Up to 85 years |
| The AUC, sensitivity, specificity and Cohen's kappa of the binary classifier distinguishing between amyloid positive (Arms 1 and 3) and amyloid negative (Arms 2 and 4) arms. | Using archival spoken or written language samples as input in the following bins: younger than 50, 50-55, 55-60, 65-70, 70-75 years old. | Up to 85 years |
| Re:Cognition Health | Recruiting | Guildford | GU2 7YD | United Kingdom |
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| Re:Cognition Health | Recruiting | London | W1G9JF | United Kingdom |
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| Re:Cognition Health | Recruiting | Plymouth | PL68BT | United Kingdom |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D060825 | Cognitive Dysfunction |
| D013060 | Speech |
| D007802 | Language |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D014705 | Verbal Behavior |
| D003142 | Communication |
| D001519 | Behavior |
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