Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices

Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices

We used a segment of cryopreserved aorta as a graft for reconstruction for long segment tracheobronchial lesion in human.

Inclusion criteria:

• Patients with advanced benign or malignant lesions involving trachea or bronchi, and has failed conventional treatment.
• Patients with proximal pulmonary tumors that require surgical resection and has involved proximal airways which is indicated for a pneumonectomy, sleeve lobectomy, or carina resection.

Exclusion criteria:

• Less than 20-year-old
• Unable to obtain informed consent.
• Pulmonary tumors that can be treated with standard lobectomy.
• Unresectable locally advanced malignant tumors
• Malignant tumors with contralateral lymph nodes involvement.
• Malignant tumors with distal metastases; except for simple resectable brain metastasis.
• Tracheal lesions which can be treated with standard resection and direct anastomosis.
• Allergic to iodine
• Unable to tolerate standard lobectomy
• Has human immunodeficiency virus infection
• Tracheal stenosis at proximal 2 cm on upper trachea