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| Name | Class |
|---|---|
| Hoffmann-La Roche | INDUSTRY |
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This study will determine the effect of cyclosporine on the PK of AT-527 (R07496998) in healthy male subjects
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AT-527 550 mg + cyclosporine (simultaneous) | Experimental | n=12 |
|
| AT-527 550 mg + cyclosporine (staggered) | Experimental | n=12 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AT-527 550 mg + cyclosporine | Drug | 550 mg AT-527 alone on Day 1 and 550 mg AT-527 plus 600 mg cyclosporine administered simultaneously on Day 7 Other Names: AT-527 is also known as R07496998 |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetics (PK) of AT-527 (R07496998): Cmax | Maximum plasma concentration (Cmax) | Day 1 vs Day 7 |
| Pharmacokinetics (PK) of AT-527 (R07496998): AUC | Area under the concentration-time curve (AUC) | Day 1 vs Day 7 |
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Inclusion Criteria:
Exclusion Criteria:
Healthy adult male subjects
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Atea Study Site | Montreal | Quebec | Canada |
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| ID | Term |
|---|---|
| C000713067 | AT-511 |
| D016572 | Cyclosporine |
| ID | Term |
|---|---|
| D003524 | Cyclosporins |
| D010456 | Peptides, Cyclic |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
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| AT-527 550 mg + cyclosporine | Drug | 550 mg AT-527 alone on Day 1 and 550 mg AT-527 plus 600 mg cyclosporine administered on Day 7 (with dosing offset by 2 hrs) Other Names: AT-527 is also known as R07496998 |
|
| D010455 |
| Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |