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This study was a Randomized Controlled Trial conducted at Ojha Institute of Chest Diseases, Dow University of Health Sciences, Karachi, among pulmonary tuberculosis patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bupropion | Experimental |
| |
| Behavioural Change Communication | Experimental |
| |
| Control | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupropion | Drug | This group received Bupropion 150 mg twice daily for 10 weeks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients completing anti-tuberculosis treatment | Among both smear positive and smear negative TB patients, successful completion of ATT will be labeled at the end of 6 months period if the patients has been compliant with ATT through six months period.. | six months |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of participants achieving abstinence from smoking | Abstinence is defined as staying away from smoking and it will be assessed at week 1, week 4, week 12 and week 24 will be assessed in following two ways: i. Self-reported abstinence using questionnaire ii. Expired carbon monoxide (eCO) levels using Micro Smokerlyzer (Bedfont Scientific) of less than 7 ppm. | six months |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients defaulting anti-tuberculosis treatment. | Treatment default will be defined as interruption of anti-tuberculosis treatment for ≥2 consecutive months. This outcome will be assessed in both smear positive and smear negative patients. | Six Months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Muhammad Tahir Rizwan Khan, M.Phil. | Dow University of Health Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dow University of Health Sciences | Karachi | Sindh | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38385711 | Derived | Khan MT, Zaheer S, Amar W, Shafique K. Effect of smoking cessation interventions on abstinence and tuberculosis treatment outcomes among newly diagnosed patients: a randomized controlled trial. Microbiol Spectr. 2024 Apr 2;12(4):e0387823. doi: 10.1128/spectrum.03878-23. Epub 2024 Feb 22. |
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| ID | Term |
|---|---|
| D014397 | Tuberculosis, Pulmonary |
| D016540 | Smoking Cessation |
| ID | Term |
|---|---|
| D014376 | Tuberculosis |
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
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| ID | Term |
|---|---|
| D016642 | Bupropion |
| ID | Term |
|---|---|
| D011427 | Propiophenones |
| D007659 | Ketones |
| D009930 | Organic Chemicals |
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A total of three groups, two intervention and one control
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Outcome assessor for tuberculosis outcomes at the study site were blinded in terms of intervention allocation
| Behavioural Change Communication |
| Behavioral |
This group will receive Behavioural Change Communication |
|
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D012141 | Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D015438 | Health Behavior |
| D001519 | Behavior |