Time interval between treatments will be provided

Time interval between visits will be provided

Duration of treatment period will be provided

Maximum period of treatment extension (where applicable)

Number of retreatments will be provided

Reasons for retreatment will be provided

The following therapy schemes are defined:

• Fixed scheme (FIX): Planned interval of (control-) visits: "regular" and planned treatment performance: "at each visit"
• Pro Re Nata (PRN): Planned interval of (control-) visits: "regular" and planned treatment performance: "as needed"
• Treat & Extend (T+E): Planned interval of (control-) visits: "variable" and planned treatment performance: "at each visit"
• Monitor & Extend (M+E): Planned interval of (control-) visits: "variable" and planned treatment performance: "as needed"

FIX, PRN, T+E and M+E are based on documentation by visit regarding physician's planning and will be applied as overall planned therapy scheme, if no different therapy schemes are documented between patient's visit.

Actual interval of (control-) visits and treatment performance will be derived using the documented visit dates and treatment documentations.

Reasons for choice of treatment regimen will be provided. The choice of treatment is described within 5 categories:

• Medical reasons
• Compability with organisation of practice/clinic
• Compability with availability of patient
• Patient's request
• Other

The results from the above derived monitoring and treatment regimen will be stratified for German patients according to the status of insurance (public health insurance or private health insurance).

Number of treatments with Lucentis® vials and pre-filled syringe will be provided