Contrast-enhanced Ultrasound With Perfluorobutane and Sulfur Hexafluoride for Hepatocellular Carcinoma

Perfluorobutane-enhanced Ultrasound as a Diagnostic Tool for Hepatocellular Carcinoma in Individuals With High Risk: Intraindividual Comparison With Sulfur Hexafluoride-enhanced Ultrasound

Intra-individual comparison of diagnostic performance of CEUS With perfluorobutane and sulfur hexafluoride for HCC in high-risk Individuals, and their role in the diagnostic algorithm of HCC.

The investigators would compare the diagnostic performance for HCC at high-risk individuals between both USG contrast agents.

Inclusion Criteria:

• high-risk for HCC (liver cirrhosis, chronic hepatitis B)
• treatment-naive hepatic nodule (>= 1cm) on preceding CT, MR or ultrasound

Exclusion Criteria:

• severe cardiopulmonary dysfunction
• pregnancy
• refusal to enroll study