Real World Effectiveness of Upadacitinib on Early and Sustained Pain Control in Axial Spondylarthritis (UPSTAND)
Real World Effectiveness of Upadacitinib on Early and Sustained Pain Control in Axial Spondylarthritis (UPSTAND)
Axial spondyloarthritis (axSpA) is an immune-mediated inflammatory disease primarily affecting the axial skeleton. The most frequent axSpA symptom is chronic, often inflammatory back pain (IBP) that might be difficult to distinguish from other causes of chronic back pain (CBP). Many participants report persistent pain, including back pain, which impacts disease activity and quality of life including creating burdens such as sleep disturbance, social isolation, loss of productivity, as well as anxiety and depression. This study will assess the real-world effectiveness of upadacitinib on early and sustained pain control, and the association between pain and clinical/patient-reported outcomes in axSpA participants.
Upadacitinib is being developed for the treatment of axSpA. Approximately 650 adult participants with active-axSpA will be enrolled across approximately 19 countries in Europe, North America, South America, and Asia-Pacific.
Participants will receive oral upadacitinib tablets as prescribed by the physician prior to enrolling in this study in accordance with the terms of the local marketing authorization and professional and reimbursement guidelines with regards to dose, population and indication. Participants will be followed for 12 months.
There may be a higher burden for participants in this study compared to usual standard of care. Participants will attend regular visits per routine clinical practice. The effect of the treatment will be checked by medical assessments, checking for side effects, and questionnaires.
Inclusion Criteria:
Exclusion Criteria:
Anderlecht, Brussels Capital 1070, Belgium
Sofia, 1000, Bulgaria
Montreal, Quebec H1T 2M4, Canada
Saskatoon, Saskatchewan S7H 5M7, Canada
Saint Priest EN Jarez, Pays de la Loire Region 42270, France
RION Patras Achaia, 26504, Greece
Kecskemét, 6000, Hungary
ADAN, Kuwait
Guadalajara, Jalisco 44650, Mexico
Poznan, Greater Poland Voivodeship 61-545, Poland
Warsaw, Masovian Voivodeship 02-637, Poland
Kaliningrad, Kaliningrad Oblast 236016, Russia
Saransk, Mordoviya, Respublika 430901, Russia
Moscow, Moscow 115522, Russia
Moscow, Moscow Oblast 129110, Russia
Samara, Samara Oblast 443095, Russia
Saint Petersburg, Sankt-Peterburg 193015, Russia
Surgut, 628400, Russia
Santiago de Compostela, A Coruna 15076, Spain
San Cristóbal de La Laguna, Santa Cruz De Tenerife 38320, Spain