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| Name | Class |
|---|---|
| Regional Specialized Hospital in Olsztyn | UNKNOWN |
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The investigators want to compare new muscle relaxation monitoring, TOF-Cuff and TOF-Scan, during general anesthesia. Standard monitoring is using thumb, however it can't be use on every patient. Alternative can be eyebrow muscle or foot muscle.
There is only few old study that compares this muscle and used mivacurium. The study aims to compare TOF-Cuff and TOF-Scan with different sensor and use mivacurium.
In our research in addition to the standard intraoperative monitoring, which includes the assessment of ECG and saturation, the investigators would like to estimate muscle relaxation by using two different methods: a TOF-Cuff which additionally allows to measure inoperative blood pressure and TOF-Scan with different sensor. Our aim is to compare two different methods of muscle relaxation monitoring in patients who will administer muscle relaxant - mivacurium. After receiving painkillers and hypnotics, when the patient is falling asleep, the standard dose of mivacurium 0.2 mg / kg body weight will be administered. Then, painless simultaneous stimulation with TOF-Cuff and TOF-Scan devices will begin. Until intubation, measurements will be made in every 30 seconds and then every 5 minutes until extubation. Extubation will take place according to the guidelines when the TOF-Cuff measurement on the arm is greater than 0.9 - this is the value at which the patient is considered ready to start breathing on his own. The following will be documented: the initiation of drug administration, intubation, possible repeated doses of mivacurium 2 mg, antagonization, extubation, possible side effects (e.g., transient cardiac disturbances, reddening of the skin, lowering blood pressure, bronchospasm, erythema, urticaria) and technical problems.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TOF Cuff on arm and TOF Scan on corrugator supercilii | Patients undergoing surgery with intubation and receiving a intubation dose of mivacurium (0.2 mg/kg) and repeated dose of mivacurium (2mg) depending of needing under, routine gas anesthesia will have monitoring of neuromuscular block with two monitors simultaneously. |
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| TOF Cuff on lower leg and TOF Scan on adductor pollicis | Patients undergoing surgery with intubation and receiving a intubation dose of mivacurium (0.2 mg/kg) and repeated dose of mivacurium (2mg) depending of needing under, routine gas anesthesia will have monitoring of neuromuscular block with two monitors simultaneously. |
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| TOF Scan on adductor pollicis and TOF Scan on toe | Patients undergoing surgery with intubation and receiving a intubation dose of mivacurium (0.2 mg/kg) and repeated dose of mivacurium (2mg) depending of needing under, routine gas anesthesia will have monitoring of neuromuscular block with two monitors simultaneously. |
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| TOF Scan on adductor pollicis and TOF Cuff on arm | Patients undergoing surgery with intubation and receiving a intubation dose of mivacurium (0.2 mg/kg) and repeated dose of mivacurium (2mg) depending of needing under, routine gas anesthesia will have monitoring of neuromuscular block with two monitors simultaneously. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TOF Cuff on arm | Device | The TOF Cuff will be installed on one arm in opposite of TOF Scan. After intubation dose of mivacurium continuous monitoring of neuromuscular block started until complete recovery of neuromuscular block. |
| Measure | Description | Time Frame |
|---|---|---|
| Onset time | Time in seconds from start of injection of mivacurium until emergence of TOF ratio of 0%. TOF = Train of Four | 1 to 10 minutes |
| Total recovery time of neuromuscular block | The total recovery time, i.e. total duration of the neuromuscular block is defined as the time in minutes from start of injection of mivacurium until a normalized TOF ratio of 90% | 30 to 500 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Time to repeated dose | Time in minuted from TOF ratio 0% to repeated dose | 5 to 200 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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In the study will take patients qualified to the elective surgery
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Anesthesiology and Intensive Care Clinical Ward, Regional Specialized Hospital | Olsztyn | Warmian-Masurian Voivodeship | 10-561 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40659829 | Derived | Radkowski P, Rusc J, Keska M, Onichimowski D. Comparison of TOF scan neuromuscular monitoring on adductor pollicis vs. corrugator supercilii and flexor hallucis brevis. Sci Rep. 2025 Jul 14;15(1):25426. doi: 10.1038/s41598-025-11259-5. |
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| TOF Scan on adductor pollicis and TOF Scan on corrugator supercilii | Patients undergoing surgery with intubation and receiving a intubation dose of mivacurium (0.2 mg/kg) and repeated dose of mivacurium (2mg) depending of needing under, routine gas anesthesia will have monitoring of neuromuscular block with two monitors simultaneously. |
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| TOF Cuff on lower leg | Device | The TOF Cuff will be installed on one lower leg. After intubation dose of mivacurium continuous monitoring of neuromuscular block started until complete recovery of neuromuscular block. |
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| TOF Scan on toe | Device | The TOF Scan will be installed on hallux . After intubation dose of mivacurium continuous monitoring of neuromuscular block started until complete recovery of neuromuscular block. |
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| TOF Scan on adductor pollicis | Device | The TOF Scan will be installed on Thumb. After intubation dose of mivacurium continuous monitoring of neuromuscular block started until complete recovery of neuromuscular block. |
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| TOF Scan on corrugator supercilii | Device | The TOF Scan will be installed on corrugator supercilii. After intubation dose of mivacurium continuous monitoring of neuromuscular block started until complete recovery of neuromuscular block. |
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