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| Name | Class |
|---|---|
| Izmir Katip Celebi University | OTHER |
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The aim of this study was to evaluate the effects of mediterranean and low-fat diet on hepatic fat, inflammation markers and oxidative stress in adolescents with nonalcoholic fatty liver disease. This randomized, single-blind controlled study conducted with obese adolescents aged 11-18 years who were admitted to Tepecik Training and Research Hospital Pediatric Gastroenterology Outpatient Clinic with the diagnosis of nonalcoholic fatty liver disease. Participants were randomly assigned to the Mediterranean diet or low-fat diet group.
This study was conducted to evaluate the effect of Mediterranean and low-fat diet on hepatic fat, inflammation and oxidative stress in obese adolescents with nonalcoholic fatty liver disease (NAFLD). The study, which was designed as a single blind randomized control, was completed with 44 obese adolescents diagnosed with NAFLD between the ages of 11-18. Adolescents were randomized to either a Mediterranean diet (n = 22) or a low-fat diet (control diet) (n = 22) for 12 weeks. At the beginning of the study and at the 12th week, adolescents' blood samples, physical activity and food consumption records were taken, anthropometric measurements and body composition analyzes were made, and antioxidant food consumption frequency and Mediterranean diet quality index questionnaire were applied to adolescents. In the controls performed at the 2th, 4th, 6th, 8th, and 10th weeks, the physical activity and food consumption records of the adolescents were repeated and anthropometric measurements and body composition analyzes were made again.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mediterrenean diet | Experimental | Mediterranean diet:Target macronutrient energy contributions were 40% from carbohydrate, 35%-40% from fat (with <10% of energy as saturated fat), and 20% of energy as protein.Participant in this group were trained to consume fish, legumes at least 2-3 times a week, walnuts and olive oil every day in accordance with the Mediterranean diet model. |
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| Low fat diet | Active Comparator | Low fat diet:Target macronutrient energy contributions for the low fat diet diet were 50-60% from carbohydrate, <30% from fat (with <10% of energy as saturated fat), and 20% from protein.Participants in this group were especially recommended to consume low-fat foods. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mediterranean diet | Other | Diet intervention:Mediterranean diet |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in hepatic steatosis | Hepatic steatosis was evaluated according to liver ultrasonography records during the routine controls of all patients. | Baseline and week 12 |
| Changes in Inflammatory Parameters | Measurement of serum cytokines levels (C-reaktive protein (CRP), IL-10, IL-6, IL-8, IL-1 beta, TNF-alpha | Baseline and week 12 |
| Changes in oxidative stress markers | Measurement of oxidative stress markers (Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON-1), Total Thiol, Native Thiol, Superoxide Dismutase (SOD), oxidized-LDL, Glutathione peroxidase,Malondialdehyde (MDA), Glutathione (GSH), non-esterified fatty acids (NEFA)) | Baseline and week 12 |
| Changes in glycemic profile | Measurement of fasting glucose, insulin, HbA1c and calculation of HOMA-IR | Baseline and week 12 |
| Changes in liver function tests | Measurement of Alanine transaminase (ALT),Aspartate transaminase (AST),Gamma-glutamyltransferase (GGT),Alkaline phosphatase (ALP) | Baseline and week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in serum cholesterol levels | Measurement of total cholesterol, LDL, HDL cholesterol | Baseline and week 12 |
| Changes in triglycerides | Measurement of serum triglyceride (mg/dl) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| İzmir Tepecik Training and Research Hospital | Izmir | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34881510 | Derived | Yurtdas G, Akbulut G, Baran M, Yilmaz C. The effects of Mediterranean diet on hepatic steatosis, oxidative stress, and inflammation in adolescents with non-alcoholic fatty liver disease: A randomized controlled trial. Pediatr Obes. 2022 Apr;17(4):e12872. doi: 10.1111/ijpo.12872. Epub 2021 Dec 8. |
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D038441 | Diet, Mediterranean |
| ID | Term |
|---|---|
| D000095500 | Diet, Plant-Based |
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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| Control diet: Low fat diet |
| Other |
Low fat diet |
|
| Baseline and week 12 |
| Changes in blood pressure | Measurement of systolic and diastolic blood pressure (mm Hg) | Baseline and week 12 |
| Changes in waist, hip and neck circumference | Measurement of waist circumference (cm) | baseline, week 2, week 4, week 6, week 8, week 10 and week 12 |
| Changes in Body Fat | Measurement of % body fat with BIA | baseline, week 2, week 4, week 6, week 8, week 10 and week 12 |
| Changes in BMI | weight and height will be measured to report BMI in kg/m2 | baseline, week 2, week 4, week 6, week 8, week 10 and week 12 |
| Changes in some adipokines | Measurement of serum leptin and adiponectin | Baseline and week 12 |
| D004032 |
| Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |