Peppermint Oil for the Treatment of Interstitial Cystitis / Bladder Pain Syndrome

Efficacy of Peppermint Oil in a Randomized, Single-Blind, Placebo Controlled Trial in Women With Interstitial Cystitis/Bladder Pain Syndrome

The purpose of this study is to assess the use of peppermint oil as a treatment for Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).

After being informed about the study and potential risks, all participants will complete validated IC/BPS symptom questionnaires for baseline screening. Once participants meet eligibility requirements and give written informed consent they will be randomized in a 1:1 ratio to peppermint oil (200mg TID) or placebo (also TID). Participants will complete validated IC/BPS questionnaires and follow up surveys over 8 weeks.

Inclusion Criteria:

• Women ages 18-65 years old
• Diagnosed with IC/BPS for at least one month prior to study enrollment

Exclusion Criteria:

• Culture proven urinary tract infection within 1 month of randomization
• Gross hematuria
• Currently pregnant or breastfeeding
• Unable to speak and read English
• History of allergic reaction to peppermint, coconut or enteric coating
• History of malabsorption syndrome
• History of gastroparesis
• History of gastric bypass surgery
• History of gastrointestinal, genitourinary or pelvic cancer in the last 5 years
• History of insulin dependent diabetes
• History of active urinary stone disease