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This project aims to measure repetition suppression and tactile prediction using high-resolution electroencephalography in preschoolers, in order to describe the responses as a function of age, gestational age of birth and the presence of a neurodevelopmental disorder. We will include 100 children aged 2 or 6 years: 25 2-year-olds born prematurely, 25 2-year-olds born at term, 25 6-year-olds with typical development and 25 6-year-olds with neurodevelopmental disorders. We will perform several behavioral evaluations to analyze the results in view of the quality of development.
We will include 100 children aged 2 or 6 years: 25 2-year-olds born prematurely, 25 2-year-olds born at term, 25 6-year-olds with typical development and 25 6-year-olds with neurodevelopmental disorders. Children will be recruited from local schools and institutions. Birth will be considered premature if children were born before 36 weeks of gestational age. Children will be considered as having neurodevelopmental disorder if they receive medical and/or paramedical care at the time of measurement for neurodevelopmental disorder, including autism spectrum disorder, attention deficit with or without hyperactivity, tics, learning disorders, but all participants must be attending school at the time of measurement.
Children will come to the lab for a 2 hours session with their parents, during which they will undergo movement, attention and executive functions evaluations. Parents will fill out questionnaires evaluating their child's executive functioning and sensory profile in home/everyday settings. Children will then be equipped with 128-channels electroencephalography and proposed two tests : a modified attention network task and a tactile prediction task.
We will calculate correlations between evoked potential amplitudes during the tactile prediction trials and inhibitory conflict trials. Results will be analysed in the light of age, gestational age at birth, ecological and psychometric evaluations, and neurodevelopmental status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preterm 2 | Experimental | 2-year-olds born prematurely |
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| Term 2 | Experimental | 2-year-olds born at term |
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| Typical 6 | Experimental | 6-year-olds with typical developement |
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| NDD 6 | Experimental | 6-year-olds with neurodevelopmental disorders |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| electroencephalography | Device | 128-channel electroencephalography |
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| Measure | Description | Time Frame |
|---|---|---|
| Repetition suppression at 2 | Difference of tactile evoked potential amplitude between end and beginning of stimulation sequence | 2 years |
| Repetition suppression at 6 | Difference of tactile evoked potential amplitude between end and beginning of stimulation sequence | 6 years |
| Tactile prediction at 2 | Difference of amplitude between baseline and omission segment | 2 years |
| Tactile prediction at 6 | Difference of amplitude between baseline and omission segment | 6 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nadege Roche-Labarbe, PhD | Contact | +33(0)649922568 | nadege.roche@unicaen.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Comete U1075 Inserm Unicaen | Recruiting | Caen | 13032 | France |
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| ID | Term |
|---|---|
| D065886 | Neurodevelopmental Disorders |
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
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| ID | Term |
|---|---|
| D004569 | Electroencephalography |
| ID | Term |
|---|---|
| D003943 | Diagnostic Techniques, Neurological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004568 | Electrodiagnosis |
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| Tactile stimulation | Device | Vibrotactile sequence on the forearm |
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| Attention Network task (computerized) | Behavioral | Computer-based game challenging orienting and executive attention. The subject must chose which side an animal is going, using left and right buttons, depending on the validity of a cue and the congruency of flankers. |
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| Head-toes-knees-schoulders | Behavioral | Following motor commands such as touch your head when they are congruent or incongruent. |
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| Laby 5-12 | Behavioral | Test of motor planning using labyrinths |
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| M-ABC 2 | Behavioral | Test of motor functions using various subtests of gross and fine motor function. |
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| Stroop animals | Behavioral | Stroop test for preK children using animals instead of words |
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| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |