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The AMPHIBIA study is an observational ambispective and prospective cohort that aim to describe the histologic, immunologic, biological, imaging, genetic and clinical characteristics of the patients hospitalized for an acute myocarditis and to evaluate their association with prognosis.
Acute myocarditis is an inflammatory disease of the heart muscle. Its clinical presentation and its etiologies are multiple and make it a complex disease to treat. Its course also varies, ranging from complete clinical recovery to recurrence of ventricular arrhythmia or progression to chronic dilated heart disease, while being difficult to predict. The long-term prognosis is poorly understood.
Consecutive patients hospitalized in a tertiary university referral center cohort from 2006 to 2041 for an acute myocarditis will be ambispectively or prospectively analyzed. This project will establish a registry including up to 400 patients in the ambispective analysis cohort from 2006 to 2021 and 1000 patients in the prospective analysis cohort during a 20 years inclusion period.
The aim of the study is to describe the characteristics of patients hospitalized for an acute myocarditis and to evaluate their association wih the long term (until 20 years) prognosis.
Features of interest will include :
The collection of clinical, biological and radiological data will represent an unique source allowing research teams in the coming years to access the data necessary to answer various specific questions (pathophysiological, diagnostic, prognostic) relevant to the state of knowledge on this pathology.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute myocarditis | Patients hospitalized for an acute myocarditis. |
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| Measure | Description | Time Frame |
|---|---|---|
| Major cardiac events | Defined as a composite of :
| up to 1 years |
| Measure | Description | Time Frame |
|---|---|---|
| Major cardiac events | Defined as a composite of :
| up to 20 years |
| All cause death |
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Inclusion Criteria:
Exclusion Criteria:
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Patients hospitalised at Pitié-Salpêtrière hospital (Paris, France) for an acute myocarditis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mathieu Kerneis, MD | Contact | +33142163001 | mathieu.kerneis@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Giles MONTALESCOT, MD, PhD | ACTION Study Group - Assistance Publique - Hôpitaux de Paris | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Pitié-Salpêtrière | Recruiting | Paris | 75013 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26063472 | Background | Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015 Aug 22;386(9995):743-800. doi: 10.1016/S0140-6736(15)60692-4. Epub 2015 Jun 7. | |
| 11334844 |
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| ID | Term |
|---|---|
| D009205 | Myocarditis |
| D009202 | Cardiomyopathies |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Whole blood 20ml
| up to 20 years |
| Cardiovascular death | up to 20 years |
| Heart transplant | Number of patients with heart transplant | up to 20 years |
| Sustained ventricular arrhythmia after discharge | Number of patients with sustained ventricular arrhythmia after discharge | up to 20 years |
| Resuscitated cardiac arrest | Number of patients with resuscitated cardiac arrest | up to 20 years |
| Longterm mechanical circulatory support | Number of patients implanted with a longterm mechanical circulatory support | up to 20 years |
| Hospitalization for myocarditis recurrence | Number of patients hospitalized for myocarditis recurrence | up to 20 years |
| Hospitalization for heart failure | Number of patients with hospitalization for heart failure | up to 20 years |
| Pericardial drainage | Number of patients with a surgery of pericardial drainage | up to 20 years |
| Supra ventricular arrythmia | Number of patients with a new onset of supra ventricular arrhythmia | up to 20 years |
| High grade atrioventricular block | Number of patients with a new high grade atrioventricular block | up to 20 years |
| Pericarditis | Number of patients with pericarditis diagnosed by the patient referring physician's | up to 20 years |
| Left ventricular systolic function under 50% | Evaluated by transthoracic echocardiography | up to 20 years |
| Therapeutics during hospital stay | Type and duration of therapeutics received during the initial hospital stay | From the day of admission up to 90 days |
| Background |
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| 19389557 | Background | Friedrich MG, Sechtem U, Schulz-Menger J, Holmvang G, Alakija P, Cooper LT, White JA, Abdel-Aty H, Gutberlet M, Prasad S, Aletras A, Laissy JP, Paterson I, Filipchuk NG, Kumar A, Pauschinger M, Liu P; International Consensus Group on Cardiovascular Magnetic Resonance in Myocarditis. Cardiovascular magnetic resonance in myocarditis: A JACC White Paper. J Am Coll Cardiol. 2009 Apr 28;53(17):1475-87. doi: 10.1016/j.jacc.2009.02.007. |
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| 29764898 | Background | Ammirati E, Cipriani M, Moro C, Raineri C, Pini D, Sormani P, Mantovani R, Varrenti M, Pedrotti P, Conca C, Mafrici A, Grosu A, Briguglia D, Guglielmetto S, Perego GB, Colombo S, Caico SI, Giannattasio C, Maestroni A, Carubelli V, Metra M, Lombardi C, Campodonico J, Agostoni P, Peretto G, Scelsi L, Turco A, Di Tano G, Campana C, Belloni A, Morandi F, Mortara A, Ciro A, Senni M, Gavazzi A, Frigerio M, Oliva F, Camici PG; Registro Lombardo delle Miocarditi. Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis: Multicenter Lombardy Registry. Circulation. 2018 Sep 11;138(11):1088-1099. doi: 10.1161/CIRCULATIONAHA.118.035319. |
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| 29025554 | Background | Aquaro GD, Perfetti M, Camastra G, Monti L, Dellegrottaglie S, Moro C, Pepe A, Todiere G, Lanzillo C, Scatteia A, Di Roma M, Pontone G, Perazzolo Marra M, Barison A, Di Bella G; Cardiac Magnetic Resonance Working Group of the Italian Society of Cardiology. Cardiac MR With Late Gadolinium Enhancement in Acute Myocarditis With Preserved Systolic Function: ITAMY Study. J Am Coll Cardiol. 2017 Oct 17;70(16):1977-1987. doi: 10.1016/j.jacc.2017.08.044. |
| 31727281 | Background | Aquaro GD, Ghebru Habtemicael Y, Camastra G, Monti L, Dellegrottaglie S, Moro C, Lanzillo C, Scatteia A, Di Roma M, Pontone G, Perazzolo Marra M, Barison A, Di Bella G; "Cardiac Magnetic Resonance" Working Group of the Italian Society of Cardiology. Prognostic Value of Repeating Cardiac Magnetic Resonance in Patients With Acute Myocarditis. J Am Coll Cardiol. 2019 Nov 19;74(20):2439-2448. doi: 10.1016/j.jacc.2019.08.1061. |
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