Assess the sensitivity of real-time near-infrared fluorescence imaging to detect microscopic residual disease in the operating room after a complete macroscopic surgical resection of head and neck cancers

Inclusion Criteria:

• Male or female 18 years of age or older
• ECOG performance status 0-2
• Histological confirmation of squamous cell carcinoma
• Locating the primary tumour in the oral cavity or oropharynx
• Disease operable for complete resection
• Serum or urinary pregnancy test (as per centre practices) negative within 14 days prior to systemic indocyanin green injection (pre-operative visit), for women of childbearing age
• Patient information and signed free and informed consent
• Patient affiliated with a social security scheme or beneficiary of a similar scheme.
• The patient must understand, sign and date the consent form prior to any protocol-specific procedures. The patient must be able and willing to comply with the study visits and procedures described in the protocol

Exclusion Criteria:

• Severe medical co-morbidities or contraindications to surgery
• Primary tumour not operable
• History of head and neck cancer in the past 5 years
• History of radiation for head and neck cancer
• Metastatic cancer
• Tumours with necrosis ranges in pre-operative imaging
• History of invasive cancer unless there has been no recurrence for more than 5 years with an exception for non-melanoma skin cancers.
• Pregnant or nursing woman
• Allergy or hypersensitivity to the product being administered (its active substance or other ingredients), iodized products or crustaceans.
• Hyperthyroidism, thyroid adenoma, unifocal, multifocal or multinodular goiter of autoimmune origin.
• Documented coronary artery disease
• Advanced renal failure (creatinine > 1.5mg/dL).
• Within 2 weeks prior to inclusion, concomitant medication that reduces or increases extinction of GI (i.e. anticonvulsants, haloperidol and Heparin).
• Patient under guardianship or curatorship or deprived of liberty by judicial or administrative decision or patient unable to give consent.
• Patients unable to undergo medical follow-up of the trial