18F-sodium fluoride (18F-NaF) was already investigated numerous times in the last 40 years as a PET alternative to standard 99m-technetium-derived bone scintigraphy. However, lack of universal tracer availability and higher costs contributed to the failure of 18F-NaF to systematically supplant bone scintigraphy as a standard of care.

Recently, an isotope shortage crisis occurred and evidenced the need to have non-reactor-derived alternatives for many nuclear medicine procedures, including bone scintigraphy. Since 18F-NaF is cyclotron-produced, it could become a necessary alternative to bone scintigraphy in case of another worldwide isotope shortage.

The study aims to evaluate the safety profile of 18F-NaF injection. Moreover, a patient registry will be compiled in order to perform sub-studies on 18F-NaF diagnostic performance on diverse bone and articular diseases.

Inclusion Criteria:

• Patients for whom a 99mTc-biphosphonate bone scintigraphy is indicated;
• Pediatric patients for whom a 99mTc-biphosphonate bone scintigraphy is indicated for oncologic or infectious reasons
• Able to tolerate supine position
• Written consent

Exclusion Criteria:

• Healthy subjects
• Pregnancy
• Unable of maintaining supine position for more than 15 minutes
• Refusal to sign the consent form
• Known allergy or hypersensitivity to 18F-NaF or any of its constituants.