Trial of Open Versus Laparoscopic Radical Cystectomy at a Laparoscopic Naive Center

Randomised Controlled Trial of Open Versus Laparoscopic Radical Cystectomy at a Laparoscopic Naive Center

This study is a prospective randomised controlled study of urinary bladder cancer patients presented to urology unit at National Cancer Institute; Cairo University.

The study will randomise 60 patients to one of two arms; laparoscopic-assisted radical cystectomy and open radical cystectomy. The focus of the study will be a comparison of both approaches on the patients' peri-operative outcome.

Inclusion Criteria:

• Patients with transitional cell carcinoma, squamous cell carcinoma and urinary bladder adenocarcinoma.
• Patients fit for surgery (ECOG Performance Status 0,1).

Exclusion Criteria:

• Patients with medical comorbidities that preclude surgical management or minimally invasive techniques.
• Patients with advanced hydronephrosis or renal failure.
• Patients refusing surgery.
• Patients with urinary bladder cancer invading bladder neck or prostatic urethra.
• Patients with metastatic urinary bladder cancer.
• Patients who received prior pelvic radiotherapy.
• Patients refusing randomization and/or participation in the trial.