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| Name | Class |
|---|---|
| Helsinki University Central Hospital | OTHER |
| Kuopio University Hospital | OTHER |
| Oulu University Hospital | OTHER |
| Turku University Hospital |
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The infants diagnosed with SVT are treated with antiarrhythmic medication to prevent the recurrence of SVT. This prospective observational cohort study evaluates efficacy and safety of shortening duration of antiarrhythmic medication to four months in infants with SVT. Primary outcome is incidence of recurrent SVT in infants after 4 months of antiarrhythmic medication compared to retrospectively reviewed cohort.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propranolol | Drug | 3 mg/kg/d, divided in four doses when age less than 3 months and in three doses when age more than 3 months | ||
| Flecainide | Drug | 80 mg/m2/d | ||
| Amiodarone | Drug | Single dose of 10 mg/kg/d 10-14 days, 5 mg/kg/d |
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence of SVT after antiarrhythmic medication | 1 year follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of participants with treatment failure | 4 months of antiarrhythmic medication | |
| Prevalence of adverse events | 4 months of antiarrhythmic medication | |
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Inclusion Criteria:
Exclusion Criteria:
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Infants age less than 6 months with SVT due to AVRT or AVNRT
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| Name | Affiliation | Role |
|---|---|---|
| Tuija Poutanen, MD | Tampere University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Central Finland Central Hospital | Jyväskylä | Central Finland | 40620 | Finland | ||
| Kajaani Central Hospital |
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| OTHER_GOV |
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| Recurrence of SVT after one year follow-up |
| 5 year |
| Kajaani |
| Kainuu |
| 87300 |
| Finland |
| Hämeenlinna Central Hospital | Hämeenlinna | Kanta-Häme | 13530 | Finland |
| Kokkola Central Hopsital | Kokkola | Keski-Pohjanmaa | 67200 | Finland |
| Lapland Central Hospital | Rovaniemi | Lapland | 96101 | Finland |
| Oulu University Hospital | Oulu | North Ostrobothnia | 90220 | Finland |
| Kuopio University Hospital | Kuopio | Northern Savonia | 70029 | Finland |
| Lahti Central Hospital | Lahti | Paijat-Hame Region | 15850 | Finland |
| Tampere University Hospital | Tampere | Pirkanmaa | 33520 | Finland |
| Vaasa Central Hospital | Vaasa | Pohjanmaa | 65130 | Finland |
| North Karelia Central Hospital | Joensuu | Pohjois-Karjala | 80210 | Finland |
| Kymenlaakso Central Hospital | Kotka | Region of Kymenlaakso | 48210 | Finland |
| Sakunta Central Hospital | Pori | Satakunta | 28500 | Finland |
| South Karelia Central Hospital | Lappeenranta | South Karelia Region | 53130 | Finland |
| Seinäjoki Central Hospital | Seinäjoki | South Ostrobothnia | 60220 | Finland |
| Mikkeli Central Hospital | Mikkeli | South Savo | 50100 | Finland |
| Turku University Hospital | Turku | Southwest | 20521 | Finland |
| Helsinki University Hospital | Helsinki | Uusimaa | 00029 | Finland |
| ID | Term |
|---|---|
| D013617 | Tachycardia, Supraventricular |
| D001145 | Arrhythmias, Cardiac |
| ID | Term |
|---|---|
| D013610 | Tachycardia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D000075224 | Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D011433 | Propranolol |
| D005424 | Flecainide |
| D000638 | Amiodarone |
| ID | Term |
|---|---|
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001572 | Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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