Evaluation of double filtration plasmapheresis combined with chemotherapy for the treatment of abnormalities of M protein or renal function due to the multiple myeloma.

Inclusion Criteria:

• Multiple myeloma patients who are diagnosed by bone marrow morphology and immunology
• Patients with stable condition after conventional treatment
• Patients with renal insufficiency or abnormal M protein
• Patients over 18 years of age
• Liver function: blood bilirubin ≤ 35μmol/L, enzymes aspartate transaminase (AST)/aka alanine aminotransferase (ALT) is less than 2 times the upper limit of normal
• Normal heart function
• Physical condition score 0-2 level (ECOG score)
• Obtain an informed consent form signed by the patient or family member

Exclusion Criteria:

• Allergies or obvious contraindications to any of the drugs involved in the plan
• Severe heart disease, including myocardial infarction and cardiac insufficiency.
• Suffering from other organ malignancies
• Active tuberculosis patients and HIV-positive patients
• At the same time suffering from other blood system diseases
• Pregnant or lactating women
• Able to understand or follow the research plan
• Past history of intolerance or allergy to similar drugs
• Patients under 18 years of age
• Participating in other clinical researchers at the same time
• There are any other circumstances that hinder the progress of the research