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The purpose of this study is to explore the potential for an association between the development of prepubertal gynecomastia and history exposure to lavender essential oil, tea tree essential oil, and other essential oils.
After being informed about the study and privacy, parents will give informed consent and complete the APICHS (Aromatic Plant Ingredient & Child Health Survey), a validated measurement tool for determining exposure to plant-based ingredients in pediatric personal care products.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pediatric Cohort | Parents of children ages 2 to 15 years old will provide data using the APICHS. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No Intervention | Other | There is no intervention; observation only. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lifetime prevalence of prepubertal gynecomastia | The number of participants who were exposed to lavender and tea tree essential oils and had ever experienced prepubertal gynecomastia | Baseline |
| Lifetime prevalence of precocious puberty | The number of participants who were exposed to lavender and tea tree essential oils and experienced prepubertal gynecomastia | Baseline |
| Endocrine Disruption - Comparison between exposed and unexposed | The difference in rates of endocrine disorders between children who were exposed to lavender or tea tree essential oil and those who were not. Exposure is measured using the Aromatic Plant Ingredient and Child Health Survey (APICHS), which measures total exposure, providing a continuous variable ranging from 0 to unlimited exposures, and a dichotomous yes/no exposure outcome variable. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Parents of children aged 2 to 15 years old who live in the United States will be recruited for this study. Emphasis is placed on obtaining a diverse sample which all states and territories, in addition to a racially and SES diverse sample.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Franklin Health Research Center | Recruiting | Franklin | Tennessee | 37067 | United States |
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| ID | Term |
|---|---|
| D006177 | Gynecomastia |
| D004700 | Endocrine System Diseases |
| ID | Term |
|---|---|
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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