the aim of our study is to enhance the dissolution and subsequently the local penetration of the drug through the sulcus in addition to controlling the drug release so that, the drug could be potentially absorbed.

Patients will be divided randomly into three groups: Group (I);will be treated with subgingival debridement and subgengival injection of chitosan 2% gel containing a microsponges formulated (SV), Group (II); will be treated with subgingival debridement and subgingival injection of chitosan 2% gel containing free (SV) and Group (III); will be treated by subgingival debridement and placebo gel injected subgingivally. Pocket depth and clinical attachment loss bone gain were recorded preoperative and six months postoperative for all groups.

Inclusion Criteria:

• patients with chronic periodontitis with minimum two sites of pocket depth > 5 mm
• patients with normal lipid profile
• nonsmokers
• patients free from any systemic disorders
• committed patients to complete the treatment with follow-ups.

Exclusion Criteria:

• patients with hyperlipidemia
• patients taking lipid lowering drugs
• smokers
• pregnant
• Lactating women women, patients with mental or psychological illness and medically compromised patients.