Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| International Renal Research Institute Vicenza | OTHER |
| University of Giessen | OTHER |
Not provided
Not provided
Not provided
Not provided
This is a monocentre randomized pilot study. All patients received two consecutive RRT: CVVHD with MCO filter (Ultraflux® EMiC®2) and post-Continuous Veno-Venous Hemodiafiltration (CVVHDF) with HFF(AV1000S®) in a controlled randomized (1:1) blinded manner. Crossover randomized to sequence (A+B or B+A) for 48 h total without washout.
This is a monocentre randomized pilot study. All patients received CVVHD with MCO filter (Ultraflux® EMiC®2) and post-Continuous Veno-Venous Hemodiafiltration (CVVHDF) with HFF(AV1000S®) in a controlled randomized (1:1) blinded manner. Crossover randomized to sequence (A+B or B+A) for 48 h total without washout.
The efficiency of the filters for small and middle molecules was compared in septic shock patients with AKI stage 3.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MCO-CVVHD | Experimental | CVVHD with MCO filter for 24 hours |
|
| HFF-CVVHDF | Active Comparator | CVVHDF with high flux filter for 24 hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultraflux® EMiC®2 | Device | Ultraflux® EMiC®2-CVVHD runs in septic shock patients with AKI KDIGO 3 for 24 hours. and patients were randomised to start Ultraflux® EMiC®2-CVVHD in the first day or in the second day from the RRT start; more precisely, crossover randomized to sequence consists in Ultraflux® EMiC®2-CVVHD (first day)+ HFF-CVVHDF(second day) and HFF-CVVHDF (first day) + Ultraflux® EMiC®2-CVVHD (second day) for 48 h total without washout |
| Measure | Description | Time Frame |
|---|---|---|
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: mean arterial pressure (MAP, mmHg) | 48 hours |
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: heart rate (HR, beat/min) | 48 hours |
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: lactate level (mmol/L) | 48 hours |
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: cardiac index (CI; L/min/m2) | 48 hours |
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: stroke volume variation (SVV; %) | 48 hours |
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: PVC (mmHg) | 48 hours |
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: SVRI (dyn*s/cm5*m2) | 48 hours |
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: SCVO2 (%) |
| Measure | Description | Time Frame |
|---|---|---|
| clerance of cytokine | removal of IL-6 (pg/mL) | 48 hours |
| clerance of cytokine | removal of IL-10 (pg/mL); reduction was evaluated after before and after the RRT |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fiorenza Ferrari | Pavia | PV | 27000 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39102092 | Derived | Ferrari F, Milla P, Sartori M, Zanza C, Tesauro M, Longhitano Y, De Silvestri A, Abbruzzese C, De Rosa S, Lassola S, Samoni S, Brendolan A, Zanella M, Scaravilli V, Grasselli G, Arpicco S, Ronco C. Antibiotics Removal during Continuous Renal Replacement Therapy in Septic Shock Patients: Mixed Modality Versus "Expanded Haemodialysis". Clin Pharmacokinet. 2024 Aug;63(8):1167-1176. doi: 10.1007/s40262-024-01397-w. Epub 2024 Aug 5. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D012772 | Shock, Septic |
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
Not provided
Not provided
All patients received two consecutive RRT (MCO-CVVHD and HFF-CVVHDF); in a controlled randomized (1:1) blinded manner. Each RRT treatment lasted 24 hours Crossover randomized to sequence (A+B or B+A) for 48 h total without washout
Not provided
Not provided
Blinding procedure was limited to the doctors who collected the data and the external statistician who performed the analysis
|
|
| 48 hours |
| improvement in haemodynamic parameters | measurements of the hemodynamic parameters: dose of vasopressor or inotropes (mcg/kg/min) | 48 hours |
| 48 hours |
| clerance of cytokine | removal of IL-8 (pg/mL); reduction was evaluated after before and after the RRT | 48 hours |
| clerance of cytokine | removal of MPO (U/L); reduction was evaluated after before and after the RRT | 48 hours |
| Efficiency for middle molecules | measure of the efficacy (Kcd, (ml/kg/h)) of removal of B2microglobulin for each filter according to equation in Neri M, Villa G, Garzotto F, Bagshaw S, Bellomo R, Cerda J, Ferrari F, Guggia S, Joannidis M, Kellum J, Kim JC, Mehta RL, Ricci Z, Trevisani A, Marafon S, Clark WR, Vincent JL, Ronco C; Nomenclature Standardization Initiative (NSI) alliance. Nomenclature for renal replacement therapy in acute kidney injury: basic principles. Crit Care. 2016 Oct 10;20(1):318. Review. | 48 hours |
| Efficiency for small molecules | measure of the efficacy (Kcd (ml/kg/h)) of BUN for each filter according to equation in Neri M, Villa G, Garzotto F, Bagshaw S, Bellomo R, Cerda J, Ferrari F, Guggia S, Joannidis M, Kellum J, Kim JC, Mehta RL, Ricci Z, Trevisani A, Marafon S, Clark WR, Vincent JL, Ronco C; Nomenclature Standardization Initiative (NSI) alliance. Nomenclature for renal replacement therapy in acute kidney injury: basic principles. Crit Care. 2016 Oct 10;20(1):318. Review. | 48 hours |
| Efficiency for small molecules | measure of Efficacy (Kcd Cr (ml/kg/h)) of removal of SCr for each filter according to equation in Neri M, Villa G, Garzotto F, Bagshaw S, Bellomo R, Cerda J, Ferrari F, Guggia S, Joannidis M, Kellum J, Kim JC, Mehta RL, Ricci Z, Trevisani A, Marafon S, Clark WR, Vincent JL, Ronco C; Nomenclature Standardization Initiative (NSI) alliance. Nomenclature for renal replacement therapy in acute kidney injury: basic principles. Crit Care. 2016 Oct 10;20(1):318. Review. | 48 hours |
| removal of antibiotics | evaluation of plasma level of vancomycin piperacillin/tazobactam(mcg/ml) | 48 hours |
| removal of antibiotics | evaluation of plasma level of vancomycin (mcg/ml) | 48 hours |
| removal of antibiotics | evaluation of plasma level of meropenem(mg/L) | 48 hours |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |