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| Name | Class |
|---|---|
| University Hospitals, Leicester | OTHER |
| University Hospital Southampton NHS Foundation Trust | OTHER |
| Azienda Ospedaliera Universitaria Integrata Verona | OTHER |
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Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD.
Twenty centers from eight European centers of cardiac surgery have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. The investigators will compare patient's comorbidities, condition at referral, surgical strategies and perioperative treatments in patients with and without early and late adverse events. The primary clinical outcome will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, transfusion of blood products and length of stay in the intensive care unit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute type A aortic dissection | Patients who underwent surgery for acute type A aortic dissection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgery on the ascending aorta with or without repair of the aortic root and/or aortic arch | Procedure | Surgical repair of the ascending aorta with or without surgical repair of the aortic root and/or aortic arch |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality rate | All-cause mortality | During the index hospital stay until last follow-up control |
| Cumulative incidence of reoperation on the aorta | Any surgical and endovascular procedure on any segment of the aorta for aortic dissection or its related complication | During the index hospital stay until last follow-up control |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of stroke | change in the level of consciousness, hemiplegia, hemiparesis, numbness, or sensory loss affecting one side of the body, dysphasia or aphasia, hemianopia, amaurosis fugax, or other neurological signs or symptoms consistent with stroke duration of a focal or global neurological deficit ≥ 24 h; OR <24 h if available neuroimaging documents a new brain hemorrhage or infarct; OR the neurological deficit results in death. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent surgical repair for acute type A aortic dissection or intramural hematoma involving the aortic root/ascending aorta.
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| Name | Affiliation | Role |
|---|---|---|
| Fausto Biancari | Helsinki University Hospital, Helsinki, Finland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AZ St-Jan | Bruges | Belgium | ||||
| Saint-Luc's Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40569847 | Derived | Demal TJ, Knochenhauer T, Weimann J, Juvonen T, Makikallio T, Fiore A, Perrotti A, Pettinari M, Peterss S, Buech J, Radner C, Dell'Aquila AM, Wisniewski K, Pol M, Kacer P, Onorati F, Francica A, Vendramin I, Piani D, Rinaldi M, Ferrante L, Quintana E, Pruna-Guillen R, Lega JR, Pinto AG, Acharya M, Field M, Kuduvalli M, Nappi F, Gerelli S, Di Perna D, Gatti G, Mazzaro E, Rosato S, D'Errigo P, Mariscalco G, El-Dean Z, Detter C, Reichenspurner H, Polvani G, Biancari F, Conradi L. Outcome after day- and nighttime surgery for acute type A aortic dissection. Eur J Cardiothorac Surg. 2025 Jun 3;67(6):ezaf192. doi: 10.1093/ejcts/ezaf192. | |
| 40081929 |
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| Centre Hospitalier Universitaire de Besancon |
| OTHER |
| Assistance Publique - Hôpitaux de Paris | OTHER |
| Ziekenhuis Oost-Limburg | OTHER |
| University Hospital Muenster | OTHER |
| University of Hamburg-Eppendorf | OTHER |
| Institute for Clinical and Experimental Medicine | OTHER_GOV |
| Northern General Hospital, Herries Road, Sheffield | UNKNOWN |
| Liverpool Heart and Chest Hospital NHS Foundation Trust | OTHER |
| University Hospital, Udine, Italy | OTHER |
| Heart Center Leipzig - University Hospital | OTHER |
| Cliniques universitaires Saint-Luc- Université Catholique de Louvain | OTHER |
| AZ Sint-Jan AV | OTHER |
| University Hospital, Antwerp | OTHER |
| Universitaire Ziekenhuizen KU Leuven | OTHER |
| University of Turin, Italy | OTHER |
| University of Barcelona | OTHER |
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| From date of procedure until the date of hospital discharge, assessed up to 3 months |
| Incidence of acute kidney injury | It will be defined according to postoperative change in serum creatinine levels and its severity will be stratified according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria | From date of procedure until the date of hospital discharge, assessed up to 3 months |
| Incidence of surgical site infection | Proven infection involving deep sternal wound tissues and/or mediastinum. | From date of procedure until the date of hospital discharge, assessed up to 3 months |
| Incidence of reoperation for bleeding | Chest reopening for excessive bleeding. | From date of procedure until the date of hospital discharge, assessed up to 3 months |
| Incidence and amount of blood transfusion | Transfusions of red blood cells | From date of procedure until the date of hospital discharge, assessed up to 3 months |
| Length of stay in the intensive care unit | Duration of stay in the intensive care unit | From date of procedure until the date of hospital discharge, assessed up to 3 months |
| Incidence of global brain ischemia | Diffuse hypoxic damage as diagnosed at brain imaging and electroencephalography. | From date of procedure until the date of hospital discharge, assessed up to 3 months |
| Incidence of paraplegia/paraparesis | Bilateral weakness and/or multimodality sensory disturbance below the level of the ischemic spinal lesion. | From date of procedure until the date of hospital discharge, assessed up to 3 months |
| Brussels |
| Belgium |
| University Hospital Antwerp | Edegem | Belgium |
| Ziekenhuis Oost-Limburg | Genk | Belgium |
| University Hospitals Leuven | Leuven | Belgium |
| Institute of Clinical and Experimental Medicine | Prague | Czechia |
| Helsinki University Hospital | Helsinki | Finland |
| Henri Mondor University Hospital | Créteil | Paris | France |
| University Hospital Jean Minjoz | Besançon | France |
| University Heart & Vascular Centre Hamburg | Hamburg | Germany |
| Leipzig Heart Center | Leipzig | Germany |
| Münster University Hospital | Münster | Germany |
| University of Torino | Torino | Italy |
| University of Udine | Udine | Italy |
| University of Verona Medical School | Verona | Italy |
| Hospital Clínic de Barcelona | Barcelona | Spain |
| University Hospitals of Leicester | Leicester | United Kingdom |
| Liverpool Heart and Chest Hospital | Liverpool | United Kingdom |
| Northern General Hospital | Sheffield | United Kingdom |
| Southampton University Hospital | Southampton | United Kingdom |
| Derived |
| Biancari F, Makikallio T, Rosato S, Juvonen T, Mariscalco G, El-Dean Z, Acharya M, Pettinari M, Rodriguez-Lega J, Pinto AG, Perrotti A, Onorati F, Wisniewski K, Conradi L, Demal T, Pol M, Rocek J, Kacer P, Gatti G, Vendramin I, Piani D, Rinaldi M, Ferrante L, Quintana E, Pruna-Guillen R, Peterss S, Buech J, Radner C, Field M, Harky A, Fiore A, Senemaud J, Mustonen C, Dell'Aquila AM, D'Errigo P, Polvani G, Di Perna D. Carotid artery dissection and neurological complications after surgery for type 1 aortic dissection. Open Heart. 2025 Mar 12;12(1):e002882. doi: 10.1136/openhrt-2024-002882. |
| 40071739 | Derived | Biancari F, Fileccia D, Ferrante L, Makikallio T, Juvonen T, Jormalainen M, Mariscalco G, El-Dean Z, Pettinari M, Rodriguez Lega J, Pinto AG, Perrotti A, Onorati F, Wisniewski K, Demal T, Kacer P, Rocek J, Di Perna D, Vendramin I, Piani D, Rinaldi M, Quintana E, Pruna-Guillen R, Peterss S, Buech J, Radner C, Kuduvalli M, Harky A, Fiore A, D'Alonzo M, Dell'Aquila AM, Gatti G, Conradi L, Ballotta A, Field M. Extent of surgical repair and outcomes after surgery for type A aortic dissection. BJS Open. 2025 Mar 4;9(2):zraf003. doi: 10.1093/bjsopen/zraf003. |
| 39840731 | Derived | Biancari F, Gatti G, Makikallio T, Juvonen T, Mariscalco G, El-Dean Z, Pettinari M, Rodriguez Lega J, Perrotti A, Onorati F, Wisniewki K, Demal T, Kacer P, Perna DD, Vendramin I, Rinaldi M, Ferrante L, Quintana E, Buech J, Radner C, Fiore A, Dell'Aquila AM, D'Errigo P, Rosato S, Polvani G, Peterss S. Ascending aortic replacement versus aortic root replacement in patients with type A aortic dissection involving the aortic root. Ther Adv Cardiovasc Dis. 2025 Jan-Dec;19:17539447241303408. doi: 10.1177/17539447241303408. |
| 39522713 | Derived | Dell'Aquila AM, Wisniewski K, Georgevici AI, Szabo G, Onorati F, Rossetti C, Conradi L, Demal T, Rukosujew A, Peterss S, Caroline R, Buech J, Fiore A, Folliguet T, Perrotti A, Herve A, Nappi F, Pinto AG, Lega JR, Pol M, Kacer P, Mazzaro E, Gatti G, Vendramin I, Piani D, Ferrante L, Rinaldi M, Quintana E, Pruna-Guillen R, Gerelli S, Di Perna D, Acharya M, Sherzad H, Mariscalco G, Field M, Harky A, Kuduvalli M, Pettinari M, Rosato S, Juvonen T, Mikko J, Makikallio T, Mustonen C, Biancari F. Malperfusion syndrome in patients undergoing repair for acute type A aortic dissection: Presentation, mortality, and utility of the Penn classification. J Thorac Cardiovasc Surg. 2025 Sep;170(3):687-697. doi: 10.1016/j.jtcvs.2024.11.003. Epub 2024 Nov 9. |
| 38768283 | Derived | Biancari F, Lega JR, Mariscalco G, Peterss S, Buech J, Fiore A, Perrotti A, Rukosujew A, Pinto AG, Demal T, Wisniewski K, Pol M, Gatti G, Vendramin I, Rinaldi M, Pruna-Guillen R, Di Perna D, El-Dean Z, Sherzad H, Nappi F, Field M, Pettinari M, Jormalainen M, Dell'Aquila AM, Onorati F, Quintana E, Juvonen T, Makikallio T. Aortic arch surgery for DeBakey type 1 aortic dissection in patients aged 60 years or younger. BJS Open. 2024 May 8;8(3):zrae047. doi: 10.1093/bjsopen/zrae047. |
| 38686961 | Derived | Juvonen T, Vendramin I, Mariscalco G, Jormalainen M, Perrotti A, Herve A, Mazzaro E, Gatti G, Pettinari M, Peterss S, Buech J, Nappi F, Pinto AG, Rodriguez Lega J, Pol M, Rocek J, Kacer P, Rukosujew A, Wisniewski K, Piani D, Demal T, Conradi L, Ferrante L, Rinaldi M, Quintana E, Pruna-Guillen R, Gerelli S, Di Perna D, Fiore A, Folliguet T, Acharya M, El-Dean Z, Field M, Kuduvalli M, Onorati F, Francica A, Makikallio T, Dell'Aquila AM, Mustonen C, Raivio P, Rosato S, Biancari F. Femoral arterial cannulation for surgical repair of stanford type A aortic dissection. World J Surg. 2024 Jul;48(7):1771-1782. doi: 10.1002/wjs.12203. Epub 2024 Apr 30. |
| 38458584 | Derived | Biancari F, Onorati F, Peterss S, Buech J, Mariscalco G, Lega JR, Pinto AG, Fiore A, Perrotti A, Herve A, Rukosujew A, Demal T, Conradi L, Wisniewski K, Pol M, Kacer P, Gatti G, Mazzaro E, Vendramin I, Piani D, Rinaldi M, Ferrante L, Pruna-Guillen R, Di Perna D, Gerelli S, El-Dean Z, Nappi F, Field M, Kuduvalli M, Pettinari M, Francica A, Jormalainen M, Dell'Aquila AM, Makikallio T, Juvonen T, Quintana E. Nature of Neurological Complications and Outcome After Surgery for Type A Aortic Dissection. Am J Cardiol. 2024 May 15;219:85-91. doi: 10.1016/j.amjcard.2024.03.001. Epub 2024 Mar 6. |
| 38458387 | Derived | Biancari F, Perrotti A, Juvonen T, Mariscalco G, Pettinari M, Lega JR, Di Perna D, Makikallio T, Onorati F, Wisniewki K, Demal T, Pol M, Gatti G, Vendramin I, Rinaldi M, Quintana E, Peterss S, Field M, Fiore A. Diameter and dissection of the abdominal aorta and the risk of distal aortic reoperation after surgery for type A aortic dissection. Int J Cardiol. 2024 Jun 1;404:131938. doi: 10.1016/j.ijcard.2024.131938. Epub 2024 Mar 7. |
| 38288052 | Derived | Biancari F, Demal T, Nappi F, Onorati F, Francica A, Peterss S, Buech J, Fiore A, Folliguet T, Perrotti A, Herve A, Conradi L, Rukosujew A, Pinto AG, Lega JR, Pol M, Rocek J, Kacer P, Wisniewski K, Mazzaro E, Vendramin I, Piani D, Ferrante L, Rinaldi M, Quintana E, Pruna-Guillen R, Gerelli S, Di Perna D, Acharya M, Mariscalco G, Field M, Kuduvalli M, Pettinari M, Rosato S, D'Errigo P, Jormalainen M, Mustonen C, Makikallio T, Dell'Aquila AM, Juvonen T, Gatti G. Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study. Front Cardiovasc Med. 2024 Jan 15;10:1307935. doi: 10.3389/fcvm.2023.1307935. eCollection 2023. |
| 37432422 | Derived | Juvonen T, Jormalainen M, Mustonen C, Demal T, Fiore A, Perrotti A, Herve A, Mazzaro E, Gatti G, Pettinari M, Peterss S, Buech J, Nappi F, Conradi L, Pinto AG, Rodriguez Lega J, Pol M, Kacer P, Dell'Aquila AM, Rukosujew A, Wisniewski K, Vendramin I, Piani D, Ferrante L, Rinaldi M, Quintana E, Pruna-Guillen R, Gerelli S, Di Perna D, Folliguet T, Acharya M, Field M, Kuduvalli M, Onorati F, Rossetti C, Makikallio T, Raivio P, Mariscalco G, Biancari F. Direct Aortic Versus Supra-Aortic Arterial Cannulation During Surgery for Acute Type A Aortic Dissection. World J Surg. 2023 Nov;47(11):2899-2908. doi: 10.1007/s00268-023-07116-z. Epub 2023 Jul 11. |
| 36912033 | Derived | Biancari F, Juvonen T, Fiore A, Perrotti A, Herve A, Touma J, Pettinari M, Peterss S, Buech J, Dell'Aquila AM, Wisniewski K, Rukosujew A, Demal T, Conradi L, Pol M, Kacer P, Onorati F, Rossetti C, Vendramin I, Piani D, Rinaldi M, Ferrante L, Quintana E, Pruna-Guillen R, Rodriguez Lega J, Pinto AG, Acharya M, El-Dean Z, Field M, Harky A, Nappi F, Gerelli S, Di Perna D, Gatti G, Mazzaro E, Rosato S, Raivio P, Jormalainen M, Mariscalco G. Current Outcome after Surgery for Type A Aortic Dissection. Ann Surg. 2023 Oct 1;278(4):e885-e892. doi: 10.1097/SLA.0000000000005840. Epub 2023 Mar 13. |
| 36826589 | Derived | Biancari F, Dell'Aquila AM, Gatti G, Perrotti A, Herve A, Touma J, Pettinari M, Peterss S, Buech J, Wisniewski K, Juvonen T, Jormalainen M, Mustonen C, Rukosujew A, Demal T, Conradi L, Pol M, Kacer P, Onorati F, Rossetti C, Vendramin I, Piani D, Rinaldi M, Ferrante L, Quintana E, Pruna-Guillen R, Lega JR, Pinto AG, Acharya M, El-Dean Z, Field M, Harky A, Kuduvalli M, Nappi F, Gerelli S, Di Perna D, Mazzaro E, Rosato S, Fiore A, Mariscalco G. Interinstitutional analysis of the outcome after surgery for type A aortic dissection. Eur J Trauma Emerg Surg. 2023 Aug;49(4):1791-1801. doi: 10.1007/s00068-023-02248-2. Epub 2023 Feb 24. |
| 34112230 | Derived | Biancari F, Mariscalco G, Yusuff H, Tsang G, Luthra S, Onorati F, Francica A, Rossetti C, Perrotti A, Chocron S, Fiore A, Folliguet T, Pettinari M, Dell'Aquila AM, Demal T, Conradi L, Detter C, Pol M, Ivak P, Schlosser F, Forlani S, Chetty G, Harky A, Kuduvalli M, Field M, Vendramin I, Livi U, Rinaldi M, Ferrante L, Etz C, Noack T, Mastrobuoni S, De Kerchove L, Jormalainen M, Laga S, Meuris B, Schepens M, El Dean Z, Vento A, Raivio P, Borger M, Juvonen T. European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria. J Cardiothorac Surg. 2021 Jun 10;16(1):171. doi: 10.1186/s13019-021-01536-5. |
| ID | Term |
|---|---|
| D000784 | Aortic Dissection |
| ID | Term |
|---|---|
| D000094665 | Dissection, Blood Vessel |
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000094683 | Acute Aortic Syndrome |
| D001018 | Aortic Diseases |
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