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| Name | Class |
|---|---|
| King Edward Medical University | OTHER |
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The purpose of studyis to compare the efficacy of phenytoin with levetiracetam for the management of children with status epilepticus.Study performa consists of demographic variables,exclusion criteria,history of epilepsy and efficacy achieved or not.
After getting informed consent 244 children with status epilepticus will be randomly classified into two groups.one group will receive levetireacetam and other group will be given phenytoin and their efficacy will be compared by observing them for breakthrough fits for next 48 hours.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intravenous levetireacetam | Experimental | Drug:Intravenous levetireacetam will be given at a loading dose of 20-30mg/kg then it will be added in maintainance dose of (5-30mg/kg/day) |
|
| intravenous phenytoin | Experimental | Intravenous phenytoin will be given in loading dose of 20mg/kg then it will be added in maintainance dose i-e 5-8mg/kg/day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intravenous levetireacetam | Drug | phenytoin is considered as control drug in the study |
|
| Measure | Description | Time Frame |
|---|---|---|
| comparison of efficacy of levetireacetam with phenytoin for the management of children with status epilepticus | the intervention will be considered efficacious if child will not have breakthrough fits for 48 hours | 48 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ayesha tariq, MBBS | Contact | 0923360495413 | docayesha86@gmail.com | |
| mohammad Haroon Hamid, MBBS,FCPS | Contact | 0923008880916 | PROFHAROON@KEMU.EDU.PK |
| Name | Affiliation | Role |
|---|---|---|
| Haroon Hamid, MBBS,FCPS | King Edward Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ayesha Tariq | Recruiting | Lahore | Punjab Province | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27089373 | Background | Smith DM, McGinnis EL, Walleigh DJ, Abend NS. Management of Status Epilepticus in Children. J Clin Med. 2016 Apr 13;5(4):47. doi: 10.3390/jcm5040047. | |
| 25304961 | Background | Abend NS, Loddenkemper T. Pediatric status epilepticus management. Curr Opin Pediatr. 2014 Dec;26(6):668-74. doi: 10.1097/MOP.0000000000000154. |
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| ID | Term |
|---|---|
| D013226 | Status Epilepticus |
| ID | Term |
|---|---|
| D012640 | Seizures |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |