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Disorders of glucose metabolism, such as impaired glucose intolerance (IGT) and diabetes mellitus (DM), frequently occur in cirrhosis. However, it has been underestimated when fasting plasma glucose (FPG) levels are considered. We aimed to evaluate who needs to be undertaken a 75-g oral glucose tolerance test (OGTT) to find underlying subclinical diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal glucose tolerance (NGT) | In the 75-g OGTT, an FPG level of < 100 mg/dL or a 120-min PG level of < 140 was diagnosed as NGT. | ||
| impaired glucose intolerance (IGT) | In the 75-g OGTT, an FPG level of 100-125 mg/dL (5.6-6.9 mmol/L) or a 120-min PG level of 140-200 mg/dL (7.8-11.1 mmol/L) was diagnosed as IGT. | ||
| newly diagnosed DM (subclinical DM) | In the 75-g OGTT, a basal FPG level ˃126 mg/dL (7.0 mmol/L) or a 120-min PG level ˃200 mg/dL (11.1 mmol/L) was considered as newly diagnosed DM (hereafter referred to as subclinical DM). |
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| Measure | Description | Time Frame |
|---|---|---|
| Survival | Overall survival | through study completion, an average of 3 year |
| Measure | Description | Time Frame |
|---|---|---|
| major complications of cirrhosis | hepatic encephalopathy (HE), the development of spontaneous bacterial peritonitis (SBP), acute kidney injury (AKI), variceal bleeding, and infection | through study completion, an average of 3 year |
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Inclusion Criteria:
Exclusion Criteria:
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patients with cirrhosis without previous diabetes history
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37697655 | Derived | Kang SH, Kim MY, Han SK, Baik SK. Subclinical diabetes confirmed by 75-g OGTT influence on the prognosis of decompensated cirrhosis. J Gastroenterol Hepatol. 2024 Jan;39(1):172-179. doi: 10.1111/jgh.16327. Epub 2023 Sep 11. |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |