Subclinical Diabetes Confirmed by 75gm-OGTT Influence on the Prognosis of Decompensated Cirrhosis

Subclinical Diabetes Confirmed by 75gm-OGTT Influence on the Prognosis of Decompensated Cirrhosis

Disorders of glucose metabolism, such as impaired glucose intolerance (IGT) and diabetes mellitus (DM), frequently occur in cirrhosis. However, it has been underestimated when fasting plasma glucose (FPG) levels are considered. We aimed to evaluate who needs to be undertaken a 75-g oral glucose tolerance test (OGTT) to find underlying subclinical diabetes.

Inclusion Criteria:

• Liver cirrhosis
• Admitted to a hospital

Exclusion Criteria:

• Previously confirmed DM
• Being treated for DM
• Standard risk factors of T2DM, such as high body mass index and family history of diabetes
• Symptoms of DM, such as increased thirst and the need to urinate
• Either hepatocellular carcinoma or other malignancy
• Hepatic failure or uncontrolled decompensation [that is, refractory ascites or active variceal hemorrhage]
• Significant illnesses such as sepsis that may have interfered with glucose metabolism
• Pancreatic dysfunction such as acute/chronic pancreatitis that may have affected glucose metabolism.