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Literature on non surgical periodontal therapy (NSPT) shows lack of clarity in reporting information on re-evaluation timing and clinical response. If the re-evaluation was done shortly after NSPT, this is also likely to have an influence on the surgical treatment plan. The aim of this prospective clinical trial is to investigate the effect of re-evaluation timing at 1-3-6 months after NSPT in terms of pocket closure, PD reduction, comprehensive treatment plan, and costs for the patient.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-surgical periodontal treatment NSPT | Experimental | Conventional staging debridement (CSD) according to the severity of periodontal disease in 2 to 4 appointments at day 0, 7, 14 and 21. Supra and subgingival scaling and polishing will be performed by the use of manual and ultrasonic instruments and oral hygiene instructions will be given. Patients will be instructed to use interdental brushes with appropriate size interdental brushes or dental floss when interdental embrasures will not allow for interdental brushing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Procedure/Surgery: Non Surgical Periodontal Therapy | Procedure | Conventional staging debridement (CSD) according to the severity of periodontal disease in 2 to 4 appointments at day 0, 7, 14 and 21. Supra and subgingival scaling and polishing will be performed by the use of manual and ultrasonic instruments and oral hygiene instructions will be given. Patients will be instructed to use interdental brushes with appropriate size interdental brushes or dental floss when interdental embrasures will not allow for interdental brushing. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in pocket closure % (0 - 100 % with higher percentage indicating better status) | Percentage of pockets ≥ 5 mm that converted to ≤4 mm at the completion of NSPT | [Time Frame: Baseline, 1 month, 3 months and 6 months after the completion of the therapy.] |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Full Mouth Plaque Score (FMPS%) (0 - 100 % with higher percentage indicating worse status) | Percentage of full mouth plaque score considering 6 sited for each tooth. | [Time Frame: Baseline, 1 month, 3 months and 6 months after the completion of the therapy.] |
| Change in Probing Pocket Depth (PD) (0 - 15 mm with higher values indicating worse outcomes. |
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Inclusion Criteria:
Exclusion criteria
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CIR Dental School | Turin | 10126 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41307322 | Derived | Baima G, Dabdoub S, Thumbigere-Math V, Ribaldone DG, Caviglia GP, Tenori L, Fantato L, Vignoli A, Romandini M, Ferrocino I, Aimetti M. Multi-Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome. J Periodontal Res. 2025 Dec;60(12):1237-1253. doi: 10.1111/jre.70055. Epub 2025 Nov 27. | |
| 38362600 | Derived |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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|
The distance between the cementoenamel junction (CEJ) and the base of the pocket. |
| [Time Frame: Baseline, 1 month, 3 months and 6 months after the completion of the therapy.] |
| Change in Clinical Attachment Level (CAL) (0 - 15 mm with higher values indicating worse outcomes. | The sum of Probing pocket depth (PD, mm) and Recession (Rec, mm) | [Time Frame: Baseline, 1 month, 3 months and 6 months after the completion of the therapy.] |
| Monetary cost for the treatment plan in € | Cost in € for the proposed treatment plan for patient at each re-evaluation timing based on the Italian Dental Association survey of charges for periodontal services for general dentists and periodontists. | [Time Frame: 1 month, 3 months and 6 months after the completion of the therapy.] |
| Baima G, Ferrocino I, Del Lupo V, Colonna E, Thumbigere-Math V, Caviglia GP, Franciosa I, Mariani GM, Romandini M, Ribaldone DG, Romano F, Aimetti M. Effect of Periodontitis and Periodontal Therapy on Oral and Gut Microbiota. J Dent Res. 2024 Apr;103(4):359-368. doi: 10.1177/00220345231222800. Epub 2024 Feb 16. |
| 37773418 | Derived | Ferrarotti F, Baima G, Rendinelli M, Citterio F, Mariani GM, Mussano F, Romano F, Romandini M, Aimetti M. Pocket closure after repeated subgingival instrumentation: a stress test to the EFP guideline for stage III-IV periodontitis. Clin Oral Investig. 2023 Nov;27(11):6701-6708. doi: 10.1007/s00784-023-05279-6. Epub 2023 Sep 29. |